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- National Institute of Neurological Disorders and Stroke: Huntington's Disease
- MayoClinic.com: Huntington's Disease
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Huntington's disease is an adult-onset, genetic brain disorder characterized by loss of muscle control and advancing deterioration of the thought processes 3. The early stages of Huntington's disease primarily affect the muscular system 23. With progressive deterioration of the brain tissue, other organ systems exhibit manifestations of the disease. The National Institute of Neurological Disorders and Stroke states that more than 15,000 adults in the United States are living with Huntington's disease as of 2010 13.
If you are experiencing serious medical symptoms, seek emergency treatment immediately.
Lack of coordination and involuntary jerking, or chorea, lead to an increased risk for falls and broken bones. In the advanced stages of Huntington's disease, loss of controlled muscular function leaves patients incapable of performing the tasks of daily living, such as:
- feeding themselves
- walking 3
People with late-stage Huntington's disease are frequently bedridden and unable to speak 3.
Final Stages of Huntington's Disease
Huntington's disease adversely affects the digestive system 3. Loss of muscle control causes chewing and swallowing difficulties. The American Speech-Language-Hearing Association notes that people with Huntington's disease typically have difficulty holding food and liquids in the mouth, initiating swallowing and clearing food from the mouth 23. Uncoordinated activity of the esophagus, which transports food from the mouth to the stomach, often leads to regurgitation of swallowed food. Eating difficulties result in progressive weight loss, a hallmark symptom of advanced Huntington's disease 3. A declining appetite may also contribute to poor nutritional intake.
Loss of muscle control usually leads to an inability to control the passage of stool. Most people with advanced Huntington's disease have fecal incontinence 3. Fecal contamination of the external opening for urine passage may lead to urinary tract infection, especially among women.
- Huntington's disease adversely affects the digestive system 3.
- Fecal contamination of the external opening for urine passage may lead to urinary tract infection, especially among women.
Swallowing normally triggers a reflex muscular contraction of the epiglottis, a piece of tissue in the throat that covers the opening to the airway to prevent food from entering the lungs. The disordered swallowing associated with Huntington's disease commonly interferes with the coordinated closure of the airway, causing frequent episodes of choking and contamination of the airway with ingested food and liquids 3. Food contamination of the lungs frequently leads to pneumonia. The Huntington's Outreach Project for Education at Stanford University reports that pneumonia is the leading cause of death among people with Huntington's disease 3.
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