DHA and DHEA, despite being similar acronyms, are two different things entirely. Docosahexaenoic acid an omega-3 fatty acid derived from food sources, while dehydroepiandrosterone is a synthetic hormone. DHA and DHEA are regulated by the U.S. Food & Drug Administration as dietary supplements and can be associated with no specific health claims. Before you use these supplements to address your health concerns, talk to your doctor.
About Docosahexaenoic Acid
In the first half-year of life, DHA is extremely important to the development of the nervous system and vision. Adults find omega-3 fatty acids such as DHA beneficial to reduce the risk of heart disease. According to the UMMC, our bodies produce minute amounts of DHA, and we also get it from the foods we eat; however, a substantial number of people living in the Western world don't consume enough foods rich in omega-3 fatty acids. Fish high in DHA include:
- bluefin tuna
In addition to food sources, DHA dietary supplements can be purchased in the form of fish oil capsules, which also contain eicosapentaenoic acid, which is another type of omega-3 fatty acid. DHA supplements can also be extracted from algae; these don't contain EPA.
- In the first half-year of life, DHA is extremely important to the development of the nervous system and vision.
- According to the UMMC, our bodies produce minute amounts of DHA, and we also get it from the foods we eat; however, a substantial number of people living in the Western world don't consume enough foods rich in omega-3 fatty acids.
DHEA Harmful Effects
However, not all of these claims have been proven through clinical studies. Side effects of fish oil supplements are generally mild and include a fishy aftertaste, loose stool and queasiness.
Your adrenal glands produce the hormone dehydroepiandrosterone at higher levels in certain times of life than in others, according to the UMMC. DHEA causes your body to produce androgens and estrogens, which are male and female sex hormones. You produce the highest levels of DHEA in your mid-20s, after which levels of DHEA go into a steady decline. The UMMC notes that levels of DHEA in people 70 years of age is around 80 percent lower than those in young adults. Reduced DHEA in older adults has been linked to health conditions such as osteoporosis, memory loss, breast cancer and heart disease. Unlike DHA, there are no dietary sources of DHEA.
- Your adrenal glands produce the hormone dehydroepiandrosterone at higher levels in certain times of life than in others, according to the UMMC.
What Is DHEA 25 Mg?
DHEA is sold in a variety of preparations including capsules, tablets, drops, topical creams and even chewing gum. Many DHEA supplements use a plant extract that comes from Mexican wild yams, although there's no evidence that wild yam extract can be converted into DHEA in your body. Suggested uses for DHEA supplements include:
- treating lupus
- irritable bowel disorder
- adrenal insufficiency
- erectile dysfunction/flagging libido
- symptoms of menopause in women
- general signs of aging
DHEA supplements are touted as synthetic hormones that purportedly can delay or turn back the aging process. However, the National Institute on Aging points out that we don't yet know how DHEA can affect the body when used for an extended amount of time. Even brief use of DHEA has been linked to liver damage. Because so few clinical studies have been conducted on DHEA, its overall safety and effectiveness is not yet known, states the NIA.
- DHEA is sold in a variety of preparations including capsules, tablets, drops, topical creams and even chewing gum.
- Many DHEA supplements use a plant extract that comes from Mexican wild yams, although there's no evidence that wild yam extract can be converted into DHEA in your body.
Cautions and Concerns
Neither DHEA or DHA is suggested for use in children or pregnant or nursing women. DHEA is not recommended for anyone under the age of 40, unless DHEA levels are known to be low. According to the Memorial Sloan-Kettering Cancer Center, DHEA comes with a litany of side effects and other cautions and concerns 12. Side effects may include mania, acne and menstrual irregularities, increased facial hair, hair loss and lowering of the voice in women. DHEA is also associated with increased risk for ovarian and breast cancer in premenopausal women; this risk is increased if you are obese. The UMMC states that there's no evidence that DHEA either helps or prevents signs of aging.
Because it may affect your hormones, it's vital that you speak with your doctor before you take DHEA supplements. Consult your doctor before using any dietary supplement if you plan to use it for health benefits, especially if you have an existing health condition or use other medications and/or supplements.
- Neither DHEA or DHA is suggested for use in children or pregnant or nursing women.
- Because it may affect your hormones, it's vital that you speak with your doctor before you take DHEA supplements.
DHEA Harmful Effects
What Is DHEA 25 Mg?
DHEA & Fish Oil
Foods High in DHEA
What Is the Difference Between HGH and DHEA?
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DHEA and Hypoglycemia
Symptoms of High Testosterone Levels in Men
Lecithin While Pregnant
The Side Effects of DHEA in Relacore
- Memorial Sloan-Kettering Cancer Center: Omega-3 (DHA)
- Memorial Sloan-Kettering Cancer Center: Dehydroepiandrosterone
- National Instutites of Health MedlinePlus. Wild yam. Updated April 18, 2018.
- National Institutes of Health MedlinePlus. DHEA. Updated May 29, 2019.
- Park SG, Hwang S, Kim JS, Park KC, Kwon Y, Kim KC. The association between dehydroepiandrosterone sulfate (DHEA-S) and bone mineral density in Korean men and women. J Bone Metab. 2017;24(1):31–36. doi:10.11005/jbm.2017.24.1.31
- von Mühlen D, Laughlin GA, Kritz-Silverstein D, Bergstrom J, Bettencourt R. Effect of dehydroepiandrosterone supplementation on bone mineral density, bone markers, and body composition in older adults: the DAWN trial. Osteoporos Int. 2008;19(5):699–707. doi:10.1007/s00198-007-0520-z
- Peixoto C, Devicari Cheda JN, Nardi AE, Veras AB, Cardoso A. The effects of dehydroepiandrosterone (DHEA) in the treatment of depression and depressive symptoms in other psychiatric and medical illnesses: A systematic review. Curr Drug Targets. 2014;15(9):901-14.
- Cleveland Clinic. Prasterone, DHEA tables or capsules (Dietary supplements).
- Archer DF. Dehydroepiandrosterone intra vaginal administration for the management of postmenopausal vulvovaginal atrophy. J Steroid Biochem Mol Biol. 2015 Jan;145:139-43. doi:10.1016/j.jsbmb.2014.09.003
- Freitas RP, Lemos TM, Spyrides MH, Sousa MB. Influence of cortisol and DHEA-S on pain and other symptoms in post menopausal women with fibromyalgia. J Back Musculoskelet Rehabil. 2012;25(4):245-52. doi:10.3233/BMR-2012-0331.
- Gómez-Santos C, Hernández-Morante JJ, Tébar FJ, et al. Differential effect of oral dehydroepiandrosterone-sulfate on metabolic syndrome features in pre- and postmenopausal obese women. Clin Endocrinol (Oxf). 2012;77(4):548-54. doi:10.1111/j.1365-2265.2011.04306.x.
- Panjari M, Davis SR. DHEA for postmenopausal women: a review of the evidence. Maturitas. 2010;66(2):172-9. doi:10.1016/j.maturitas.2009.12.017
Lisa Sefcik has been writing professionally since 1987. Her subject matter includes pet care, travel, consumer reviews, classical music and entertainment. She's worked as a policy analyst, news reporter and freelance writer/columnist for Cox Publications and numerous national print publications. Sefcik holds a paralegal certification as well as degrees in journalism and piano performance from the University of Texas at Austin.