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Long-Term Effects of Wellbutrin

By James Clark ; Updated October 25, 2017

Wellbutrin is a prescription medication used to treat depression. Wellbutrin is associated with a variety of side effects which can, in some cases, be considered long-term. Talk to your doctor if you are experiencing side effects as a result of taking Wellbutrin as he may need to adjust your dosage.


Wellbutrin is a tablet which is taken orally. Take it exactly as directed. Do not alter your dosage of Wellbutrin, and do not ingest too much of this medication as an overdose can cause seizures.


Side effects of Wellbutrin can last for hours after taking the pill, or for several days and occasionally for longer durations. If symptoms are particularly bothersome, your doctor may prescribe an alternative to Wellbutrin. Effects which can be considered short or long-term include lack of sexual interest, headache, trouble sleeping, dizziness, sweating or mild rash.

Severe Effects

Get immediate medical help if you have a severe side effect after taking Wellbutrin. Severe side effects of Wellbutrin have the potential to be fatal. Side effects include hives, difficulty breathing, and facial swelling of the lips, throat, or tongue. Additional effects include seizures, blistering, mood changes, anxiety, panic attack, fever or confusion.


Some drugs interact with Wellbutrin which may cause prolonged side-effects. Drugs which may interact with Wellbutrin include other antidepressants, cancer drugs, high blood pressure medicines as well as heart medications, antihistimine or asthma drugs, birth control or diet pills, insulin, narcotics, Prednisone, bladder or kidney medications and medication for motion sickness.


Some activities while performed using Wellbutrin can cause side effects to get worse. Avoid drinking Alcohol while using Wellbutrin, as it can cause seizures to occur. Additionally, Wellbutrin can cause an inability to make sound judgments. Avoid driving or operating machinery until you are sure how this drug will affect your system.

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