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- Schon MP, Boehncke WH. Psoriasis. N Engl J Med. 2005; 352:1899-912.
- Schon MP, Boehncke WH. Psoriasis. N Engl J Med. 2005; 352:1899-912.
- Gottlieb AB. Psoriasis: emerging therapeutic strategies. Nat Rev Drug Discov. 2005;4:19-34.
- Gottlieb AB. Psoriasis: emerging therapeutic strategies. Nat Rev Drug Discov. 2005;4:19-34.
- Krueger JG, Browcock A. Psoriasis pathophysiology: current concepts of pathogenesis. Ann Rheum Dis. 2005; 64(suppl.2):ii30-6.
- Krueger JG, Browcock A. Psoriasis pathophysiology: current concepts of pathogenesis. Ann Rheum Dis. 2005; 64(suppl.2):ii30-6.
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Tests and Diagnosis for Psoriasis
Since other inflammatory diseases of the skin (like eczema) can be confused with psoriasis, it is important that a board-certified dermatologist makes the diagnosis.
Physical Examination
The dermatologist will examine the outer arms, legs and scalp. The nails need to be examined because there may be visible pits in the nails that appear much like hammered brass when the disease is flared or active. In addition, the tongue may manifest as a geographic tongue, which has white scale in a ring-like pattern.
Typically, a thorough physical examination of the scalp, skin and nails is enough to make an accurate diagnosis. Although the size of an individual lesion may vary from pinpoint to over 20 centimeters in diameter, the outline of the lesion is usually circular, oval or polycyclic (derived from several smaller units or with many sides).
Psoriasis lesions characteristically have a very sharp border and do not fade into normal skin like other inflammatory skin rashes. In addition, psoriatic lesions are sometimes surrounded by a pale blanching ring, which is commonly referred to as a Woronoff ring. The surface of psoriasis plaques at times can be removed 2. When this happens, a characteristic Auspitz sign is observed, which refers to a collection of pinpoint bleeding.
- The dermatologist will examine the outer arms, legs and scalp.
- In addition, the tongue may manifest as a geographic tongue, which has white scale in a ring-like pattern.
Skin Biopsy
Bump on the Finger Joint
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A skin biopsy may be necessary if the dermatologist is considering other similar inflammatory skin rashes, such as eczema, seborrheic dermatitis, dermatomyositis, lichen planus, pityriasis rosea or tinea corporis (ringworm).
After a local anesthesia injection with lidocaine (to numb the skin) and epinephrine (to control bleeding), a plastic device is used to remove three to four millimeters of skin. Many times a simple stitch or two is necessary, which will need to be removed in two weeks. The tissue is then examined under a microscope by a dermatopathologist to confirm the diagnosis.
- A skin biopsy may be necessary if the dermatologist is considering other similar inflammatory skin rashes, such as eczema, seborrheic dermatitis, dermatomyositis, lichen planus, pityriasis rosea or tinea corporis (ringworm).
- After a local anesthesia injection with lidocaine (to numb the skin) and epinephrine (to control bleeding), a plastic device is used to remove three to four millimeters of skin.
The Psoriasis Area and Severity Index
Because the percentage of body surface area is important in regards to deciding which treatment would be appropriate for each individual patient, a scale for measuring the number and thickness of psoriasis plaques was developed. The most widely used measuring scale is called the PASI score. This stands for Psoriasis Area and Severity Index 2. These scores can be used in both clinical and research settings.
- Because the percentage of body surface area is important in regards to deciding which treatment would be appropriate for each individual patient, a scale for measuring the number and thickness of psoriasis plaques was developed.
- The most widely used measuring scale is called the PASI score.
Other Tests
How to Remove Dead Skin From Psoriasis
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Radiographs assessing for joint disease may be useful in patients also suffering from psoriatic arthritis. Blood testing for inflammatory markers, such as a CRP or ESR level, may also be helpful. A rheumatologist typically makes this diagnosis because he or she studies autoimmune diseases that affect the joints.
It will then be necessary to determine a treatment regimen, which many times involves both topical creams, lifestyle and diet changes and possibly systemic oral or injectable medication, depending upon the severity of the condition. Many times collaboration with both the dermatologist and rheumatologist is necessary for optimal patient outcome.
- Radiographs assessing for joint disease may be useful in patients also suffering from psoriatic arthritis.
- Blood testing for inflammatory markers, such as a CRP or ESR level, may also be helpful.
Related Articles
References
- Schon MP, Boehncke WH. Psoriasis. N Engl J Med. 2005; 352:1899-912.
- Gottlieb AB. Psoriasis: emerging therapeutic strategies. Nat Rev Drug Discov. 2005;4:19-34.
- Krueger JG, Browcock A. Psoriasis pathophysiology: current concepts of pathogenesis. Ann Rheum Dis. 2005; 64(suppl.2):ii30-6.
- Rendon A, Schäkel K. Psoriasis Pathogenesis and Treatment. Int J Mol Sci. 2019;20(6):1475. doi:10.3390/ijms20061475
- Asz-sigall D, Tosti A, Arenas R. Tinea Unguium: Diagnosis and Treatment in Practice. Mycopathologia. 2017;182(1-2):95-100. doi:10.1007/s11046-016-0078-4
- Haneke E. Nail psoriasis: clinical features, pathogenesis, differential diagnoses, and management. Psoriasis (Auckl). 2017;7:51–63. doi:10.2147/PTT.S126281
- Maidhof W, Hilas O. Lupus: an overview of the disease and management options. P T. 2012;37(4):240–249.
- Simpson CL, Patel DM, Green KJ. Deconstructing the skin: cytoarchitectural determinants of epidermal morphogenesis. Nat Rev Mol Cell Biol. 2011;12(9):565–580. doi:10.1038/nrm3175
- Kim, W.; Jerome, D.; and Yeung, J. Diagnosis and management of psoriasis. Can Fam Physician. 2017 Apr; 63(4):278-85.
- Young, M.; Aldredge, L.; and Parker, P. Psoriasis for the primary care practitioner. J Am Assn Nurse Pract. 2017 Mar;29(3):157-78. doi:10.1002/2327-6924.12443
Writer Bio
Board-certified in dermatology and pediatrics, and fellowship-trained in pediatric dermatology, Cynthia Price, M.D., is dedicated to providing excellent, innovative and compassionate patient care. She specializes in adult, pediatric, and cosmetic dermatology. She is in private practice in Scottsdale, Arizona. Dr. Price trained at the University of Arizona, UCLA and the University of Miami – one of the top dermatology training programs in the country – where she was honored to serve as chief resident.