Zinc Carnosine Side Effects
The simple answer to what the side effects if zinc carnosine are is short--none. Dr. Hilda Maldonado, a board certified specialist in internal medicine, writing for a 2003 edition of "Applied Nutritional Science Reports," says zinc carnosine relieves dyspeptic gastric symptoms and intestinal mucosal disorders with no significant side effects, and is well tolerated in prescribed doses. However, excess use can lead to overdoses of both zinc and carnosine, with side effects ranging from mild to severe.
Maldonado reports that 25 to 40 percent of Americans report suffering indigestion, with heartburn, upset stomach, nausea, and bloating at least once every year. Zinc carnosine has been prescribed by physicians in Japan since 1994 for indigestion and healing of the gastric lining. The combination of zinc and carnosine is three times as effective as zinc sulfate or carnosine alone. Carnosine is a dipeptide, a protein fragment, made of two amino acids, beta-alanine and histidine. According to a 2001 U.S. Food and Drug Administration, FDA, report, the recommended daily dose of 75 mg of zinc carnosine will produce a dietary intake of 17 to l 8 mg of zinc, and 57 to 58 mg of L-carnosine.
- Maldonado reports that 25 to 40 percent of Americans report suffering indigestion, with heartburn, upset stomach, nausea, and bloating at least once every year.
- According to a 2001 U.S. Food and Drug Administration, FDA, report, the recommended daily dose of 75 mg of zinc carnosine will produce a dietary intake of 17 to l 8 mg of zinc, and 57 to 58 mg of L-carnosine.
Zinc Side Effects
Side Effects of Too Much or Not Enough Zinc
Excess zinc carnosine can produce a zinc overdose. Zinc is a metallic mineral, essential for life, found in some foods, and added as a dietary supplement to others. You can also buy zinc cold lozenges and as over-the-counter nutritional support. Zinc, according to the U.S. Office of Dietary Supplements, is important in many aspects of cell metabolism, catalyzes the activity of about 100 enzymes, promotes immune functions, wound healing, protein and DNA synthesis. You also need zinc for your sense of taste and smell. Your body can not store zinc, so intake must be constantly balanced between under- and over-dosing. Zinc toxicity leads to loss of appetite, nausea, vomiting, diarrhea, abdominal cramps and headaches. Side effects of overdose may occur within 30 minutes of ingestion. Intake of 150 to 450 mg of zinc per day can alter necessary copper and iron metabolism, disrupt immune function, and reduce your "good" HDL levels. Even much lower zinc intakes of 60 mg per day can produce these effects after 10 weeks. Doses of 80 mg per day for a few years can disrupt urinary and kidney functions. These doses far exceed the FDA recommended daily dose of 17 to 18 mg of zinc in 75 mg of zinc carnosine per day.
- Excess zinc carnosine can produce a zinc overdose.
- Intake of 150 to 450 mg of zinc per day can alter necessary copper and iron metabolism, disrupt immune function, and reduce your "good" HDL levels.
Carnosine Side Effects
Carnosine is considered very safe, according to Ultimate Fat Burner.com, with few side effects when used within recommended dosage guidelines. Children taking carnosine to treat autism symptoms may become more hyperactive, though it may simply relate to increased activity as autistic symptoms lessen. Carnosine is a popular body-building dietary supplement which enhances muscle strength and quickness. Even in extremely large doses, side effects are not noted.
- Carnosine is considered very safe, according to Ultimate Fat Burner.com, with few side effects when used within recommended dosage guidelines.
- Carnosine is a popular body-building dietary supplement which enhances muscle strength and quickness.
Side Effects of Too Much or Not Enough Zinc
Zinc and Heart Palpitations
Magnesium, Testosterone & Zinc
Side Effects of Zinc Lozenges
Zinc and Bananas
Zinc Citrate Side Effects
Can You Overdose on Zinc?
Zinc for Nail Growth
Does Zinc Deficiency Affect Our Taste Buds?
Sodium Molybdate in Food
- Oakwayhealthcenter.com: Zinc-Carnosine: Gastric Mucosal Health and Dyspeptic Symptom Relief
- Gut: Zinc Carnosine, a Health Food Supplement That Stabilises Small Bowel Integrity and Stimulates Gut Repair Processes
- Office of Dietary Supplements: Zinc
- Vitamins.ultimatefatburner.com: L-Carnosine Benefits and Side Effects
- Artioli GG, Sale C, Jones RL. Carnosine in health and disease. Eur J Sport Sci. 2019;19(1):30-39.
- Herculano B, Tamura M, Ohba A, Shimatani M, Kutsuna N, Hisatsune T. β-alanyl-L-histidine rescues cognitive deficits caused by feeding a high fat diet in a transgenic mouse model of Alzheimer's disease. J Alzheimers Dis. 2013;33(4):983-97. doi:10.3233/JAD-2012-121324
- Hisatsune T, Kaneko J, Kurashige H, et al. Effect of anserine/carnosine supplementation on verbal episodic memory in elderly people. J Alzheimers Dis. 2016;50(1):149-59. doi:10.3233/JAD-150767
- Kaneko J, Enya A, Enomoto K, Ding Q, Hisatsune T. Anserine (beta-alanyl-3-methyl-L-histidine) improves neurovascular-unit dysfunction and spatial memory in aged AβPPswe/PSEN1dE9 Alzheimer's-model mice. Sci Rep. 2017;7(1):12571. doi:10.1038/s41598-017-12785-7
- Janssen B, Hohenadel D, Brinkkoetter P, et al. Carnosine as a protective factor in diabetic nephropathy: association with a leucine repeat of the carnosinase gene CNDP1. Diabetes. 2005;54(8):2320-2327. doi:10.2337/diabetes.54.8.2320
- De Courten B, Jakubova M, De Courten MP, et al. Effects of carnosine supplementation on glucose metabolism: Pilot clinical trial. Obesity. 2016;24(5):1027-1034. doi:10.1002/oby.21434
- Mikuła-Pietrasik J, Książek K. L-Carnosine Prevents the Pro-cancerogenic Activity of Senescent Peritoneal Mesothelium Towards Ovarian Cancer Cells. Anticancer Res. 2016;36(2):665-71.
- Arner P, Henjes F, Schwenk JM, et al. Circulating carnosine dipeptidase 1 associates with weight loss and poor prognosis in gastrointestinal cancer. PLoS One. 2015;10(4):e0123566. doi:10.1371/journal.pone.0123566
- Lofthouse N, Hendren R, Hurt E, Arnold LE, Butter E. A review of complementary and alternative treatments for autism spectrum disorders. Autism Res Treat. 2012;2012:870391. doi:10.1155/2012/870391
- Guiotto A, Calderan A, Ruzza P, Borin G. Carnosine and Carnosine-Related Antioxidants: a Review. Curr Med Chem. 2005;12(20):2293-315.
- Hipkiss AR. Carnosine and Its Possible Roles in Nutrition and Health. Adv Food Nutr Res. 2009;57:87-154.
- Hipkiss AR. Would Carnosine or a Carnivorous Diet Help Suppress Aging and Associated Pathologies? Ann N Y Acad Sci. 2006 May;1067:369-74.
- Hipkiss AR. Could Carnosine or Related Structures Suppress Alzheimer's Disease? J Alzheimers Dis. 2007 May;11(2):229-40.
- Mendelson Scott D. Nutritional Supplements and Metabolic Syndrome. "Metabolic Syndrome and Psychiatric Illness." 2008.
- Quinn PJ, Boldyrev AA, Formazuyk VE. Carnosine: its properties, functions and potential therapeutic applications. Mol Aspects Med. 1992;13(5):379-444.
Walt Pickut has published peer-reviewed medical research since 1971. Pickut teaches presentational speaking and holds board registries in respiratory care and sleep technology. He is a member of the Society of Professional Journalists and the American Society of Business Publication Editors and is editor for "The Jamestown Gazette." Pickut holds bachelor's degrees in biology and communication, and master's degrees in physiology and mass communication.