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At Healthfully, we strive to deliver objective content that is accurate and up-to-date. Our team periodically reviews articles in order to ensure content quality. The sources cited below consist of evidence from peer-reviewed journals, prominent medical organizations, academic associations, and government data.
- Carcinogenesis: Nrf2 Enhances Resistance of Cancer Cells to Chemotherapeutic Drugs, the Dark Side of Nrf2
- Carcinogenesis: Nrf2 Enhances Resistance of Cancer Cells to Chemotherapeutic Drugs, the Dark Side of Nrf2
- Food Chemistry: Cytotoxicity and DNA Damage Properties of Tert-Butylhydroquinone (TBHQ) Food Additive
- Food Chemistry: Cytotoxicity and DNA Damage Properties of Tert-Butylhydroquinone (TBHQ) Food Additive
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TBHQ Side Effects
TBHQ is the acronym used to describe tertiary butylhydroquinone, which is an antioxidant that comes from petroleum and is related to butane. It is often used as a preservative, applied directly onto food, such as high-fat prepackaged and processed food items and fast food. Like many chemicals, if taken in great excess, it can be toxic. Although more research needs to be done, side effects have not thus far been clinically demonstrated in the quantities that people usually eat.
TBHQ Usage
TBHQ reduces what is referred to as oxidative deterioration in foods it is applied to -- in other words, it acts as preservative by delaying the onset of rancidness. It also therefore extends shelf life of processed foods.
TBHQ Toxicity
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As a food additive, the FDA allows TBHQ to make up no more than 0.02 percent of the total oils in a food, according to a report in the 2004 "European Food Safety Authority Journal." Consuming up to a gram of TBHQ can cause variable toxicity, and up to 5 grams can be fatal. For perspective, it would take 312.5 fast food chicken nuggets, if they contain a full 0.02 percent of TBHQ, to consume a single gram.
Side Effects
But the sheer amount of food consumption necessary to be afflicted by TBHQ toxicity generally makes these symptoms extremely rare.
Cancer Causing Potential
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In toxicity studies, long-term, high-dose TBHQ administration in lab animals was linked to the development of cancerous precursors in the stomach, as well as DNA damage. But unlike other antioxidant additives, it did not cause lung lesions in laboratory animals. However, TBHQ can make cancer cells resistant to chemotherapy agents, according to a study in the June 2008 issue of "Carcinogenesis," and a study in the June 2014 issue of "Food Chemistry" notes that TBHQ can fragment DNA and cause damage to human lung and umbilical cells 23.
- In toxicity studies, long-term, high-dose TBHQ administration in lab animals was linked to the development of cancerous precursors in the stomach, as well as DNA damage.
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Writer Bio
Ryan is a history and science buff who makes his living teaching and traveling abroad in various locations, and is currently an English instructor in South Korea. He loves nonfiction and really good fiction (Cormac McCarthy, for example), and is a bit of a computer dweeb as well.