What does fact checked mean?
At Healthfully, we strive to deliver objective content that is accurate and up-to-date. Our team periodically reviews articles in order to ensure content quality. The sources cited below consist of evidence from peer-reviewed journals, prominent medical organizations, academic associations, and government data.
The information contained on this site is for informational purposes only, and should not be used as a substitute for the advice of a professional health care provider. Please check with the appropriate physician regarding health questions and concerns. Although we strive to deliver accurate and up-to-date information, no guarantee to that effect is made.
Estrace Cream is a vaginal cream containing the estrogen hormone 13. The prescription medication works to balance postmenopausal changes in a woman’s vagina. Common conditions treated with Estrace Cream include vaginal dryness, itching and painful intercourse 1. Although Estrace Cream is used vaginally, the medication can be absorbed into the body and affect other areas of the body, causing unwanted adverse reactions 1. Some serious side effects may occur while using the medication. Women need full medical examinations with a complete medical history before starting any hormone replacement therapy program 2.
If you are experiencing serious medical symptoms, seek emergency treatment immediately.
Common Side Effects
Breast tenderness and pain, enlarged breasts, headaches, bloating, stomach cramping, nausea or vomiting. The medication may cause a loss of hair, weight changes, dizziness, bloating and mood swings. A restart of vaginal bleeding can occur after beginning the use of Estrace Cream 1. The medicine can cause bleeding as heavy as a menstrual period or spotting. Women currently still experiencing a menstrual period may experience breakthrough bleeding or other change in normal bleeding patterns. Some women may experience a change in libido, either an increase or a decrease.
- Breast tenderness and pain, enlarged breasts, headaches, bloating, stomach cramping, nausea or vomiting.
- The medicine can cause bleeding as heavy as a menstrual period or spotting.
Less Common Side Effects
Premarin Vaginal Cream Side Effects
Some women may experience an infection, such as vaginitis or yeast. Abdominal pain, cramping and diarrhea can occur during Estrace Cream use 1. Less common reactions includes inflammation of the pancreas and gallbladder disease. Some women may have changes in the shape of the eyes, causing an inability to wear contact lenses.
- Some women may experience an infection, such as vaginitis or yeast.
Serious Side Effects
Using Estrace Cream has the potential to cause serious, life threatening side effects 1. A study in 2002, conducted by the Women’s Health Initiative, concluded that taking estrogen increases the chance of developing uterine cancer, breast cancer, stroke, heart disease, heart attacks and blood clots.
Premarin Vaginal Cream Side Effects
Differences Between Scabies Rash & Eczema Rash
How to Treat Acne With Hydrocortisone
Causes of Vaginal Labia Itching
Ketoconazole Cream Uses
Side Effects of Nortrel Birth Control
Side Effects for Women Who Take Flomax Medicine
Monistat 3 Combination Pack Side Effects
Junel Side Effects
What Are the Causes of Postmenopausal Spotting?
- Drugs.com: Estrace Cream
- Dr Susan Love Research Foundation: Hormone Replacement Therapy
- Mayo Clinic: Estrogen (Vaginal Route)
- Zhang XM, Lv F, Wang P, et al. Estrogen supplementation to progesterone as luteal phase support in patients undergoing in vitro fertilization: systematic review and meta-analysis. Medicine (Baltimore). 2015;94(8):e459. doi:10.1097/MD.0000000000000459
- U.S. National Library of Medicine DailyMed. Label: Estrace—estradiol tablet. Updated May 31, 2018.
Abigail Adams began her freelance writing career in 2009, teaching others about medical conditions and promoting wellness by writing on online health and fitness publications. She is educated and licensed as a registered nurse, having received her degree from North Georgia College and State University.