Prexum Side Effects

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Prexum, sold generically as perindopril, is a drug that is used to treat individuals suffering from high blood pressure. The use of Prexum can lead to a number of mild to severe side effects depending on the particular individual.


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Prexum is a prescription drug that is classified as an ACE (angiotensin converting enzyme) inhibitor. According to, it is used to treat hypertension (high blood pressure) and prevent heart attack in individuals with heart disease. Prexum works by blocking certain chemicals in the body that naturally constrict blood vessels.

Common Side Effects

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Common side effects associated with the use of Prexum include arm and leg pain, nausea, general weakness, diarrhea, dizziness, drowsiness, back pain, cough, headache, and mild depression. Contact your doctor immediately if any of the preceding side effects worsen or become persistent. Worsening common side effects may be a sign of a serious condition.

Severe Side Effects

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According to, the use of Prexum can lead in rare cases to the following side effects: "change in the amount of urine; chest pain; darkening of urine; difficulty swallowing; fainting; fast or irregular heartbeat; fever; hoarseness; pounding in the chest; prolonged nausea, vomiting, or diarrhea; severe lightheadedness or fainting; sore throat; swelling of the hands, legs, face, lips, eyes, throat, tongue, or trunk; unusual joint pain; unusual muscle pain, cramps, or weakness; unusual stomach pain; yellowing of the skin or eyes." Seek immediate medical attention if any of these severe side effects occur.


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Always take as directed by your doctor. Never alter the recommended dose or duration of use. Prexum should be taken with a full glass of water and can be taken with or without food. The use of food with your dose can decrease the potential for upset stomach. Drink plenty of fluids because the use of Prexum can lead to dehydration. Store at room temperature.


iDmitry Kalinovsky/iStock/Getty Images reports that "this drug can cause serious fetal harm if used during the last 6 months of pregnancy." Stop using Prexum as soon as you become pregnant. Use with caution in children and the elderly. Since Prexum can cause dizziness, be careful when driving or operating machinery.