L-Carnitine Side Effects
L-carnitine is taken as a body building supplement and as a means of treating carnitine deficiency, according to the University of Maryland Medical Center 2. While L-carnitine is naturally produced in healthy bodies, there are a number of illnesses that can cause deficiency. Supplements can improve health in some circumstances, but they also carry a risk of side effects.
If you are experiencing serious medical symptoms, seek emergency treatment immediately.
Nausea and Vomiting
The Linus Pauling Institute notes that common side effects of taking L-carnitine supplements are nausea and vomiting 1. These symptoms are not considered to be severe side effects. For most individuals, the nausea and vomiting will be relatively mild.
Diarrhea
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Supplements may cause diarrhea, reports the University of Maryland Medical Center 2. This side effect is especially seen in individuals who are taking more than 5 g of L-carnitine per day. The University of Maryland Medical Center reports that this is generally a mild and passing symptom 2. Reducing dosage levels may reduce the incidence of diarrhea as a side effect.
Skin Rashes
Though not linked to any specific allergic reaction, L-carnitine has been linked to skin rashes according to the University of Maryland Medical Center 2. This is considered a rare side effect, and may be more likely to occur in users who are taking high dosages.
Fishy Body Odor
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For individuals who are doing a high-dose supplementation course, L-carnitine can change their personal body odor. The Linus Pauling Institute notes that supplements that deliver more than 3,000 mg per day are associated with a fishy body odor. This side effect is considered to be a rare side effect by the University of Maryland Medical Center, and the odor should disappear when dosages are reduced 2.
Agitation and Seizures
Depending on the age and medical history of the individual taking supplements, L-carnitine has been linked to agitation and seizure 2. The Linus Pauling Institute notes that some Alzheimer's patients taking supplements have been reported to become more agitated, although this is considered to be a rare side effect of L-carnitine 1. For individuals with a history of seizure disorders, the supplement may cause an increase in the frequency and severity of the seizures experienced.
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References
- Linus Pauling Institute: Micronutrient Information Center: L-Carnitine
- University of Maryland Medical Center: Carnitine (L-carnitine)
- Galloway, S. D., Craig, T. P., & Cleland, S. J. (2011). Effects of oral L-carnitine supplementation on insulin sensitivity indices in response to glucose feeding in lean and overweight/obese males. Amino Acids, 41(2), 507-515.
- Wall, B. T., Stephens, F. B., ConstantinâTeodosiu, D., Marimuthu, K., Macdonald, I. A., & Greenhaff, P. L. (2011). Chronic oral ingestion of lâcarnitine and carbohydrate increases muscle carnitine content and alters muscle fuel metabolism during exercise in humans. The Journal of Physiology, 589(4), 963-973.
- Ho, J. Y., Kraemer, W. J., Volek, J. S., Fragala, M. S., Thomas, G. A., Dunn-Lewis, C., ... & Maresh, C. M. (2010). l-Carnitine l-tartrate supplementation favorably affects biochemical markers of recovery from physical exertion in middle-aged men and women. Metabolism, 59(8), 1190-1199.
- Volek, J. S., Kraemer, W. J., Rubin, M. R., Gómez, A. L., Ratamess, N. A., & Gaynor, P. (2002). L-Carnitine L-tartrate supplementation favorably affects markers of recovery from exercise stress. American Journal of Physiology-Endocrinology and Metabolism, 282(2), E474-E482.
- Kraemer, W. J., Volek, J. S., French, D. N., Rubin, M. R., Sharman, M. J., Gómez, A. L., ... & Hakkinen, K. (2003). The effects of L-carnitine L-tartrate supplementation on hormonal responses to resistance exercise and recovery. The Journal of Strength & Conditioning Research, 17(3), 455-462.
- Spiering, B. A., Kraemer, W. J., Vingren, J. L., & Hatfield, D. L. (2007). Responses of criterion variables to different supplemental doses of L-carnitine L-tartrate. Journal of Strength and Conditioning Research, 21(1), 259.
- Atalay, G. N., Erikoglu, O. G., Sezen, B. F., & Coskun, C. S. (2015). Effects of acute L-carnitine supplementation on nitric oxide production and oxidative stress after exhaustive exercise in young soccer players. The Journal of Sports Medicine and Physical Fitness, 55(1-2), 9-15.
- Stephens, F. B., Constantin-Teodosiu, D., Laithwaite, D., Simpson, E. J., & Greenhaff, P. L. (2006). Insulin stimulates L-carnitine accumulation in human skeletal muscle. The FASEB Journal, 20(2), 377-379.
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Jamie Simpson is a researcher and journalist based in Indianapolis with more than 10 years of professional writing experience. She earned her B.S. in animal science from Purdue University and her Master of Public Affairs in public management from Indiana University. Simpson also works as a massage therapist and equine sports massage therapist.