Thyroid peroxidase helps in overall thyroid function 1. Yet, as with overall hormone production within the gland, thyroid peroxidase can pose health problems if its production levels get out of control 1. Higher levels of thyroid peroxidase are common in those with Graves' disease and Hashimoto’s disease 1.
The thyroid is an organ in the throat that is the shape of a butterfly and about the size of a quarter. Hormones are released by the thyroid that help to that certain bodily functions--such as blood pressure, metabolism and heart functions-- are working properly. Thyroid peroxidase (TPO) is an antibody that can help or disrupt the production of hormones, depending on their working levels 1.
- The thyroid is an organ in the throat that is the shape of a butterfly and about the size of a quarter.
- Hormones are released by the thyroid that help to that certain bodily functions--such as blood pressure, metabolism and heart functions-- are working properly.
What Does Low TSH Level Mean?
Thyroid peroxidase is a type of enzyme produced in the thyroid 1. This enzyme plays a vital role in helping the thyroid gland produce hormones, specifically triiodothyronine (T3) and thyroxine (T4) hormones. If TPO levels are too high, it can indicate that an autoimmune problem exists, thus disrupting the production of T3 and T4 hormones.
A TPO test measures the amount of antibodies that exist in the thyroid gland 13. Such tests are administered in order to detect thyroid dysfunction, or as a follow-up test to T3, T4, and Thyroid Stimulating Hormone (TSH) tests 1. An endocrinologist may recommend a TPO tests for patients who exhibit symptoms of hypothyroidism, or before a patient begins taking medications that could lead to hypothyroidism.
What Is Third Generation TSH?
A TPO test will read as positive if a thyroiditic condition exists. In patients who have hypothyroidism, this is indicative of Hashimoto’s disease. In hyperthyroid patients, this is indicative of the autoimmune condition of Graves' disease. Moderate thyroid peroxidase levels may indicate that a patient has thyroid cancer, anemia, rheumatoid arthritis or Type 1 diabetes 1. A high level of thyroid peroxidase means that a patient has Graves' disease or Hashimoto’s disease 1.
- A TPO test will read as positive if a thyroiditic condition exists.
- In patients who have hypothyroidism, this is indicative of Hashimoto’s disease.
Untreated thyroid peroxidase can lead to reproductive problems in women 1. Such difficulties include infertility, miscarriage, premature delivery and pre-eclampsia. When Graves' disease and Hashimoto’s disease are left untreated, it can necessitate surgical removal of the thyroid gland.
What Does Low TSH Level Mean?
What Is Third Generation TSH?
Are Vitamin D Deficiency & Hypothyroidism Related?
Dangerously High TSH Level
What Are the Causes of Increased TSH Levels?
What Does a High TSH Level Mean?
Normal Range for Thyroid Level
Symptoms of High TSH Levels
What Is a Normal T4 Thyroid Level?
Side Effects of Thyroid Medication
- Thyroid Peroxidase Test
- American Thyroid Association
- Thyroid Antibodies
- American Thyroid Association. General Information/Press Room.
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- The National Institute of Diabetes and Digestive and Kidney Diseases. Hyperthyroidism (Overactive Thyroid). Published August 2016.
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- Haugen A, Alexander K., Bible K, et. al. 2015 American Thyroid Association Management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer. Thyroid. 2016;26(1):1-133. doi:10.1089/thy.2015.0020
- Smallridge R, Ain K, Asa S, et. al. American Thyroid Association guidelines for management of patients with anaplastic thyroid cancer. Thyroid. 2012;22(11). doi:10.1089/thy.2012.0302
- Wells, S, Asa S, Dralle H, et. al. Revised American Thyroid Association guidelines for the management of medullary thyroid carcinoma. Thyroid. 2015;25(6). doi:10.1089/thy.2014.0335
Kristeen Cherney began writing healthy lifestyle and education articles in 2008. Since then, her work has appeared in various online publications, including Healthline.com, Ideallhealth.com and FindCollegeInfo.com. Cherney holds a Bachelor of Arts in communication from Florida Gulf Coast University and is currently pursuing a Master of Arts in English.