High Iron Levels and Liver Damage
Iron is needed for the formation of blood, muscles and enzymes -- it plays a key role in your body's ability to produce energy, and also helps you transport oxygen. However you only need a few milligrams of iron daily -- 18 for pre-menopausal women and 8 for post-menopausal women -- and your body also stores iron in your liver to serve as a temporary stand-in if you're aren't getting enough iron from your diet. However, because iron gets stored in your liver, excessively high iron levels can affect the health of your liver and pose a health risk.
Causes
Generally, you'll only develop iron toxicity if you take iron supplements at a high dosage, or take unnecessary supplements for a long period of time. The extra iron the supplements gets stored in your liver tissue, and eventually reaches toxic levels. A genetic condition, called hemochromatosis, also puts you at risk for iron toxicity, because it causes your body to absorb too much iron from foods and supplements, even if you already have enough iron in your system.
Effects
Iron Supplements & Liver Damage
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Taking a single dose of iron that is too high can cause you to vomit or have diarrhea. If you've taken a very large dose, this can also pose a serious health risk, causing brain damage, coma and death. Chronic over-cosumption damages your liver tissue, and can also damage your stomach, kidneys and heart. Symptoms of hemochromatosis vary and often don't show up until middle age. They may include abdominal pain, impotence, fatigue and joint pain.
- Taking a single dose of iron that is too high can cause you to vomit or have diarrhea.
- Chronic over-cosumption damages your liver tissue, and can also damage your stomach, kidneys and heart.
Symptoms and Signs of Liver Damage
Liver damage associated with iron overload can cause jaundice -- a yellowing of your skin and eyes caused by the leeching of chemicals out of the damaged liver tissue. In a blood test, this tissue damage would also manifest as elevated liver enzymes. Liver damage can also cause your urine to darken, due to the presence of bilirubin, a chemical given off by the damaged liver cells. Your stool might also appear pale because of a lack of bile secreted by the liver.
- Liver damage associated with iron overload can cause jaundice -- a yellowing of your skin and eyes caused by the leeching of chemicals out of the damaged liver tissue.
- Liver damage can also cause your urine to darken, due to the presence of bilirubin, a chemical given off by the damaged liver cells.
Treatment
How Long Does Iron Stay in Your System?
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To prevent damage to the liver from high levels of iron, you need treatment as soon as possible. An iron overdose is often treated by an injection of deferoxamine, which attaches to the excess iron and brings it out of the body through your urine. If the high iron levels are caused by hemochromatosis, bloodletting is the most common cure.
Considerations
If you have hemochromatosis, it is important to get treated early and regularly. Bloodletting can remove the excess iron for a time, but it can't repair the damage that has been caused by the condition before treatment starts. The sooner you get treated, the less damage will be caused to your liver. If you have family members with the condition, a genetic test can indicate whether you are at risk for hemochromatosis.
- If you have hemochromatosis, it is important to get treated early and regularly.
- If you have family members with the condition, a genetic test can indicate whether you are at risk for hemochromatosis.
Related Articles
References
- National Digestive Diseases Information Clearinghouse: Hemochromatosis
- MedlinePlus: Hemochromatosis
- Merck Manuals: Iron
- Linus Pauling Institute: Iron
- Ohio State University: Common Characteristics of Liver Disease
- Abbaspour N, Hurrell R, Kelishadi R. Review on iron and its importance for human health. J Res Med Sci. 2014;19(2):164–174.
- National Heart, Lung, and Blood Institute. Iron-Deficiency Anemia.
- Vaucher P, Druais PL, Waldvogel S, Favrat B. Effect of iron supplementation on fatigue in nonanemic menstruating women with low ferritin: a randomized controlled trial. CMAJ. 2012;184(11):1247-54. doi:10.1503/cmaj.110950
- Stugiewicz M, Tkaczyszyn M, Kasztura M, Banasiak W, Ponikowski P, Jankowska EA. The influence of iron deficiency on the functioning of skeletal muscles: experimental evidence and clinical implications. Eur J Heart Fail. 2016;18(7):762-73. doi:10.1002/ejhf.467
- Cherayil BJ. The role of iron in the immune response to bacterial infection. Immunol Res. 2011;50(1):1–9. doi:10.1007/s12026-010-8199-1
- Jáuregui-lobera I. Iron deficiency and cognitive functions. Neuropsychiatr Dis Treat. 2014;10:2087-95. doi:10.2147/NDT.S72491
- Cleveland Clinic. How to Tell If You Have Iron Deficiency Anemia. Updated October 30, 2017.
- Murat S, Ali U, Serdal K, et al. Assessment of subjective sleep quality in iron deficiency anaemia. Afr Health Sci. 2015;15(2):621–627. doi:10.4314/ahs.v15i2.40
- Dosman CF, Brian JA, Drmic IE, et al. Children with autism: effect of iron supplementation on sleep and ferritin. Pediatr Neurol. 2007;36(3):152-8. doi:10.1016/j.pediatrneurol.2006.11.004
- Office of Dietary Supplements. Iron Fact Sheet for Health Professionals. Updated October 16, 2019.
Writer Bio
Based in Massachusetts, Jessica Bruso has been writing since 2008. She holds a master of science degree in food policy and applied nutrition and a bachelor of arts degree in international relations, both from Tufts University.