What Are the Causes of Low Plasma Protein?

Conditions including kidney disease, autoimmune disorders, dietary malnutrition and malnutrition caused by infectious diseases often cause low plasma protein levels. Low plasma protein, also called hypoproteinemia, can greatly contribute to adverse outcomes of these conditions.

Major Causes

Some diseases such as kidney disease manifest from other adverse health conditions such as diabetes, obesity and heart disease. The National Diabetes Information Clearinghouse says that, because these conditions can result in kidney damage and the kidneys normally filter proteins into the blood, malfunctioning kidneys play a large role in many instances of hypoproteinemia.

Other Causes

Hepatic Encephalopathy Low-Protein Diet

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According to National Diabetes Information Clearinghouse, severe malnutrition, including low protein intake and nutrition loss because of infectious diseases such as Dengue and malaria, also causes low plasma protein. Autoimmune disorders can also cause hypoproteinemia because of developing blood cell irregularities that ultimately affect major organs such as the kidneys.

Importance of Protein

Most major body organs such as the heart, liver and kidneys begin to malfunction without enough protein present in the blood.


Why Are My Total Protein Levels Low?

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Only a laboratory test can verify low plasma protein levels in the blood, but common symptoms include foamy urine or blood in the urine as well as edema. Any disease that causes kidney damage may lead to hypoproteinemia.


According to the National Kidney and Urologic Diseases Information Clearinghouse, treatment of this condition largely depends on the treatment for the actual disease causing low plasma protein. Severe cases could require dialysis or major organ transplants if the cause of hypoproteinemia is left untreated.