Symptoms of Lymphoproliferative Disease

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Lymphoproliferative disease also is known as Castleman disease. Castleman disease means your lymphatic system grows lymphatic cells that are of unusual size. The disease also may be referred to as angilfollicular lymph node hyperplasia or just lymph node hyperplasia. It is a rare disease that is undergoing study by the National Human Genome Research Institute, which calls it autoimmune lymphoproliferative syndrome.

Unicentric Castleman Disease

Unicentric Castleman disease presents itself by affecting only one lymph node that typically may be in the abdomen or chest. The Mayo Clinic states that most often thereare no symptoms of this form of the disease. However, sometimes unicentric Castleman disease does present some symptoms. These may include a sensation you are full without eating, which also may be felt as pressure in the abdomen or chest. This condition may give you problems with your breathing or when attempting to eat. Other symptoms include anemia or a lack of red blood cells, sweating that is excessive, a slight fever, fatigue, a loss of weight or a rash on the skin.

Multicentric Castleman Disease

Multicentric Castleman disease typically affects more than one lymph node. Because your lymphatic system helps to fight infections, and because it is spread throughout your body, sufferers of multicentric Castleman disease may experience a range of symptoms. You may get a fever or experience night sweats that can drench your bedclothes. You may get damage in your nerves, particularly in your feet and hands, which produces weakness or numbing called peripheral neuropathy. Other symptoms may include an appetite loss, vomiting, nausea, a loss of weight, fatigue, weakness, lymph nodal swelling particularly in the groin, under your arms, in the collarbone area and your neck.


Autoimmune lymphoproliferative syndrome may produce some symptoms that are similar to those in both versions of Castleman disease. It also may induce such symptoms as liver enlargement—something also possible with multicentric Castleman disease—nosebleeds that are frequent, overproduction of T cells classified as double negative, spleen enlargement and white blood cells that remain active after the need for them has gone away. The National Human Genome Research Institute also states ALPS can alter a gene in your body.