Fat Soluble Versus Water Soluble Statins

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High cholesterol remains a health issue of concern in the United States. According to the Centers for Disease Control and Prevention, just over one-third of American adults over age 20 had high LDL, or "bad," cholesterol levels. Of that number, less than one-half are being treated to manage their condition and reduce their risk for heart disease. Statin drugs are a class of prescription medication used to lower LDL and total cholesterol levels. The IMS Institute for Healthcare Informatics estimates that Americans spent nearly $20 billion in 2010 on cholesterol medication. However, these drugs differ in their solubility.

What Are Statin Drugs?

Statin drugs include familiar names such as Lipitor and Crestor. These drugs lower total cholesterol to reduce your risk of a heart attack or stroke by targeting the liver and its role in cholesterol production. These drugs can be either fat or water soluble, denoting the substance in which they dissolve. This basic difference can make an impact on the effects these drugs have. Fat-soluble statins include lovastatin, simvastatin and atorvastatin. Water-soluble statins include pravastatin, fluvastatin and rosuvastatin. These drugs may be available as generics or as brand-name medications, depending upon the type.

Blood-Brain Barrier

The concern regarding their solubility rests with the possible impacts they have on brain function. Normally, your brain is protected by the blood-brain barrier that prevents toxins from entering the brain tissues. Water-soluble statins cannot enter your brain, but fat-soluble statins can. In addition to your liver, your brain also produces cholesterol. The question remains whether or not fat-soluble statin drugs can affect brain function.

Cholesterol and the Brain

Your brain uses cholesterol in order to produce neurotransmitters. These chemicals provide a means for nerve impulses to travel. They regulate some of the most basic of life functions. For example, serotonin regulates sleep and blood pressure. Noradrenaline affects your nervous system's fight-or-flight response to stress and stimuli from the environment. If statins lower total cholesterol, the concern is their impact on brain cholesterol and its uses.


Scientists are delving into this question of statin drugs and the brain. A study by the Parque Tecnológico de Ciencias de la Salud in Spain, published in the January 2011 issue of the “Journal of Alzheimer's Disease,” found that fat-soluble statin drugs provide a protective effect on the brain, though the precise mechanism is unclear. Researchers tested nine statin drugs and found that simvastatin, sold as Zocor, provided the best protection. The fact that these statin drugs are fat soluble may mean they offer additional health benefits than water-soluble medications. If you have concerns, discuss the use of statin drugs with your doctor.