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At Healthfully, we strive to deliver objective content that is accurate and up-to-date. Our team periodically reviews articles in order to ensure content quality. The sources cited below consist of evidence from peer-reviewed journals, prominent medical organizations, academic associations, and government data.
- The Harvard Medical School; Grapefruit and Medication: A Cautionary Note; February 2006
- MayoClinic.com; Antibiotics and Alcohol: Should I Avoid Mixing Them?; James M. Steckelberg; March 2010
The information contained on this site is for informational purposes only, and should not be used as a substitute for the advice of a professional health care provider. Please check with the appropriate physician regarding health questions and concerns. Although we strive to deliver accurate and up-to-date information, no guarantee to that effect is made.
Grapefruit & Augmentin
Whenever you start a new medication, whether it is temporary or permanent, you should always talk to your doctor or pharmacist about foods that may interact with it. Eating certain foods can increase or decrease a medication's effectiveness, or increase side effects. Grapefruit and its juice interact with a number of medications; however, Augmentin is not one of those medications 1.
Augmentin
Augmentin is a type of penicillin antibiotic 1. It consists of a combination of amoxicillin and clavulanate potassium. Both components are antibiotics that fight infection. However, clavulanate potassium fights bacteria that are resistant to penicillin. Augmentin is prescribed to treat a number of bacterial infections, including pneumonia, sinusitis, ear infections, bronchitis, urinary tract infections and skin infections 1. You should not take Augmentin if you are allergic to penicillin or clavulanate potassium 1. You should also talk to your doctor before taking Augmentin if you have a history of liver disease 1.
Grapefruit
Can I Take Benicar & Eat Grapefruit?
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Grapefruit is a healthy food, rich in vitamin C, potassium and fiber, and has even earned the American Heart Association's "heart check" mark. However, a substance in grapefruit juice binds with the enzyme in your gut that helps prevent the absorption of certain medications. By blocking this enzyme, the grapefruit juice allows more of the medication to enter your bloodstream, causing higher than normal blood levels of the medication, which can be dangerous. Grapefruit interacts with high blood pressure medications, cholesterol-lowering medications and psychiatric medications. However, it does not interact with any antibiotics or Augmentin 1. While it does not appear that grapefruit or its juice interacts with Augmentin, you should talk to your doctor about whether it is safe to drink grapefruit juice while taking the antibiotic 1.
- Grapefruit is a healthy food, rich in vitamin C, potassium and fiber, and has even earned the American Heart Association's "heart check" mark.
- By blocking this enzyme, the grapefruit juice allows more of the medication to enter your bloodstream, causing higher than normal blood levels of the medication, which can be dangerous.
Food and Augmentin Interactions
When it comes to diet and Augmentin, it is recommended that you take it with a full glass of water before a meal to prevent stomach upset 1. No specific foods are noted to interact with the medication, according to Drugs.com 1. However, when taking any antibiotics it is recommended that you avoid foods high in acid, such as tomato sauce or vinegars, at the time you take your medication because they can decrease your body's ability to absorb the medication. You should also avoid alcohol when taking antibiotics to lessen the severity of side effects.
Considerations
Interactions of Cranberry Juice & Amoxicillin
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Antibiotics kill not only the bad bacteria that makes you sick, but also the good bacteria that helps to keep you healthy. To restore the balance of good bacteria to your body when taking Augmentin, you should include probiotics on your diet plan 1. Probiotics are foods that contain the friendly bacteria, and include yogurt, sauerkraut and kim chee.
Related Articles
References
- Drugs.com: Augmentin
- The Harvard Medical School; Grapefruit and Medication: A Cautionary Note; February 2006
- MayoClinic.com; Antibiotics and Alcohol: Should I Avoid Mixing Them?; James M. Steckelberg; March 2010
- Soukavong M, Kim J, Park K, et al. Signal Detection of Adverse Drug Reaction of Amoxicillin Using the Korea Adverse Event Reporting System Database. J Korean Med Sci. 2016;31(9):1355-61. doi:10.3346/jkms.2016.31.9.1355
- Stein GE, Gurwith MJ. Amoxicillin-potassium clavulanate, a beta-lactamase-resistant antibiotic combination. Clin Pharm. 1984;3(6):591-9.
- Thomas VM, Thomas-eapen N. An Uncommon Side Effect of a Commonly Used Antibiotic: Amoxicillin-Clavulanic Acid Induced Hepatitis. Korean J Fam Med. 2017;38(5):307-310. doi:10.4082/kjfm.2017.38.5.307
- Millard G. Further experience with augmentin in the treatment of skin infections. Scott Med J. 1982;27 Spec No.:S35-8. doi:10.1177/00369330820270S108
- Blaser M. Antibiotic overuse: Stop the killing of beneficial bacteria. Nature. 2011;476(7361):393-4. doi:10.1038/476393a
- Zaman SB, Hussain MA, Nye R, Mehta V, Mamun KT, Hossain N. A Review on Antibiotic Resistance: Alarm Bells are Ringing. Cureus. 2017;9(6):e1403. doi:10.7759/cureus.1403
- Amoxil, Moxatag (amoxicillin) dosing, indications, interactions, adverse effects, and more.
- Augmentin, Augmentin XR (amoxicillin/clavulanate) dosing, indications, interactions, adverse effects, and more.
Writer Bio
Jill Corleone is a registered dietitian and health coach who has been writing and lecturing on diet and health for more than 15 years. Her work has been featured on the Huffington Post, Diabetes Self-Management and in the book "Noninvasive Mechanical Ventilation," edited by John R. Bach, M.D. Corleone holds a Bachelor of Science in nutrition.