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Glumetza & Weight Loss

By Maura Shenker ; Updated July 18, 2017

Glumetza is a brand-name of the drug metformin, a medication designed to control blood sugar in Type 2 diabetics. It also is used for weight loss by non-diabetics. Metformin works by preventing your liver from producing excess glucose while simultaneously increasing your body's sensitivity to insulin. By regulating glucose and insulin production, you can stabilize blood sugar and increase satiety. Reducing hunger can lead to a decrease in calorie consumption and weight loss.


Glumetza is an extended release tablet that should be taken once daily -- commonly in the evening with diner; but you should always follow your doctor's recommendations for use. Typical doses range from 500 mg to 2,000 mg, depending on your normal eating habits and regular activity level. Metformin, the active ingredient of Glumetza, can be used by people without diabetes and Typoe 2 diabetics, but should not be taken by people with Type 1 diabetes because their pancreas does not produce any insulin.

Glumetza and Weight Loss

Glumetza increases satiety, helping you feel full eating fewer calories. Weight loss requires you to burn more calories than you consume; it takes a 3,500-calorie deficit to lose 1 lb. If you can trim 500 calories from your daily diet, you should lose 1 lb. each week. Glumetza does not block your body from absorbing calories; instead it helps to lower glucose and insulin levels which reduces cravings that can lead to overeating. You'll still need to follow a balanced diet and exercise regularly.

Weight Loss and Metformin

Although metformin can help you lose weight, it's not as effective as diet and lifetsyle changes. The Diabetes Prevention Program studied more than 3,200 people trying to lose weight and prevent Type 2 diabetes. It concluded that behavior modifications such as following a low-calorie, low-fat diet and exercising at least 30 minutes daily most days of the week was almost twice as effective as simply using metformin for sustainable weight loss and delaying the onset of Type 2 diabetes.


Taking too much Glumetza can cause low blood sugar -- hypoglycemia -- which may result in headaches, mood swings, dizziness and fatigue. According to, up to 20 percent of people using Glumetza may experience gastrointestinal distress, including diarrhea or upset stomach. The most serious side effect of metformin is rare, but potentially fatal -- a build-up of lactic acid in your bloodstream. Called lactic acidosis, symptoms include somnolence, abdominal pain, vomiting and hypothermia. People with kidney or liver problems, heart disease or a history of alcohol abuse are at a higher risk for lactic acidosis.

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