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Resveratrol, a natural polyphenolic compound, is produced by a variety of plants, such as grapes, peanuts and some berries, in response to various biotic and abiotic stresses, including stress, injury, UV-radiation and bacterial and fungal infection. Emerging scientific evidence suggests that resveratrol might be a potent anticancer candidate. The antitumor actions are largely attributed to the antioxidant property of resveratrol. It is also available as a dietary supplement. Consult your doctor to determine whether resveratrol supplements are safe for you.
If you are experiencing serious medical symptoms, seek emergency treatment immediately.
As of 2011, there have not been many clinical trials and observations to determine the optimal pharmacological doses of resveratrol. The results of several animal studies conducted by the New York Langone Medical Center suggest that daily doses of 500mg of resveratrol might be safe and potent.
Standardized Grape Seed Extract
How Much Resveratrol to Take
Resveratrol from grape seeds has been widely studied for its potential chemopreventive and therapeutic effects. Grape seeds are preventive agents against various human diseases associated with free radicals, including diabetes, heart disease and cancer. Grape seed extract is available as a supplement in several forms such as capsules, tablets and liquid extracts. The University of Maryland Medical Center recommends 25mg to 150mg of a standardized grape seed extract per day to protect your body from oxidative damage caused by free radicals 2.
- Resveratrol from grape seeds has been widely studied for its potential chemopreventive and therapeutic effects.
- The University of Maryland Medical Center recommends 25mg to 150mg of a standardized grape seed extract per day to protect your body from oxidative damage caused by free radicals 2.
Optimal Therapeutic Dosage
Although resveratrol reportedly prevents or treats many human ailments in animal models, few published studies have examined the optimal therapeutic dosage. For adults, the recommended dose for resveratrol supplementation is 40mg daily, according to Dr. Johan Auwerx, a resveratrol researcher at the Huntington College of Health Sciences 1. Preliminary studies reviewed by the Linus Pauling Institute at Oregon State University have shown that trans-resveratrol is absorbed more efficiently by the body, but more studies are needed to evaluate the bioavailability of these interesting polyphenols in humans 3.
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As of 2011, the most recent evidence suggests that resveratrol has no prominent side effects. However, further studies are needed to ensure its safety for pregnant and nursing women. Be on the safe side and avoid its use until more information is available. Resveratrol is a natural supplier of estrogen, a female reproductive hormone that fuels the development of breast cancer. Therefore, women at high risk of breast cancer should not consume resveratrol. Resveratrol may also decrease the therapeutic effects of anticoagulants, such as warfarin, and could increase the risk of bleeding.
- As of 2011, the most recent evidence suggests that resveratrol has no prominent side effects.
- Resveratrol may also decrease the therapeutic effects of anticoagulants, such as warfarin, and could increase the risk of bleeding.
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- Huntington College of Health Sciences; Resveratrol: What the Research Shows; Gene Bruno; 2008
- University of Maryland Medical Center; Grape seed; August 26, 2010
- Oregon State University Linus Pauling Institute; Resveratrol; Jane Higdon; 2005
- Chung JH, Manganiello V, Dyck JR. Resveratrol as a calorie restriction mimetic: therapeutic implications. Trends Cell Biol. 2012;22(10):546‐554. doi:10.1016/j.tcb.2012.07.004
- Liu Y, Ma W, Zhang P, He S, Huang D. Effect of resveratrol on blood pressure: a meta-analysis of randomized controlled trials. Clin Nutr. 2015;34(1):27‐34. doi:10.1016/j.clnu.2014.03.009
- Sahebkar A, Serban C, Ursoniu S, et al. Lack of efficacy of resveratrol on C-reactive protein and selected cardiovascular risk factors--Results from a systematic review and meta-analysis of randomized controlled trials. Int J Cardiol. 2015;189:47‐55. doi:10.1016/j.ijcard.2015.04.008
- Semba RD, Ferrucci L, Bartali B, et al. Resveratrol Levels and All-Cause Mortality in Older Community-Dwelling Adults. JAMA Intern Med. 2014;174(7):1077‐1084. doi:10.1001/jamainternmed.2014.1582
- Tan L, Wang W, He G, et al. Resveratrol inhibits ovarian tumor growth in an in vivo mouse model. Cancer. 2016;122(5):722‐729. doi:10.1002/cncr.29793
- Poschner S, Maier-Salamon A, Zehl M, et al. Resveratrol Inhibits Key Steps of Steroid Metabolism in a Human Estrogen-Receptor Positive Breast Cancer Model: Impact on Cellular Proliferation. Front Pharmacol. 2018;9:742. doi:10.3389/fphar.2018.00742
- Heebøll S, Kreuzfeldt M, Hamilton-Dutoit S, et al. Placebo-controlled, randomised clinical trial: high-dose resveratrol treatment for non-alcoholic fatty liver disease. Scand J Gastroenterol. 2016;51(4):456‐464. doi:10.3109/00365521.2015.1107620
- Mukherjee S, Dudley JI, Das DK. Dose-Dependency of Resveratrol in Providing Health Benefits. Dose Response. 2010;8(4):478‐500. doi:10.2203/dose-response.09-015.Mukherjee
- Weiskirchen S, Weiskirchen R. Resveratrol: How Much Wine Do You Have to Drink to Stay Healthy? Adv Nutr. 2016;7(4):706‐718. doi:10.3945/an.115.011627
- American Heart Association. Is drinking alcohol part of a healthy lifestyle? Updated December 30, 2019.
Henry Pitot has been writing since 1992. His work has appeared in leading peer-reviewed journals, including "The Lancet" and Cancer Research Online. He is certified in oncology and hematology by the American Board of Internal Medicine. He received his Doctor of Medicine from University of Wisconsin in 1986.