What does fact checked mean?
At Healthfully, we strive to deliver objective content that is accurate and up-to-date. Our team periodically reviews articles in order to ensure content quality. The sources cited below consist of evidence from peer-reviewed journals, prominent medical organizations, academic associations, and government data.
The information contained on this site is for informational purposes only, and should not be used as a substitute for the advice of a professional health care provider. Please check with the appropriate physician regarding health questions and concerns. Although we strive to deliver accurate and up-to-date information, no guarantee to that effect is made.
Vitamins and minerals are essential micronutrients and an important part of a balanced and healthy diet. Both vitamins and minerals interact with a number of cells and tissues within your body, allowing for proper cellular function to keep your body strong and healthy. While vitamin and mineral supplementation can prove beneficial, especially in individuals suffering from nutrient deficiencies, consuming large doses of some vitamins and minerals can lead to unpleasant digestive upset.
One vitamin that can upset your stomach when taken in large doses is vitamin C, also called ascorbic acid. Vitamin C plays an essential role in tissue maintenance by promoting the production of collagen -- a protein that makes up a portion of your bones, blood vessels, tendons and ligaments. Although moderate doses of vitamin C prove beneficial to the body, consuming large doses of the vitamin can lead to nausea, or other forms of digestive upset such as diarrhea. To prevent adverse side effects of taking vitamin C supplements, limit your vitamin C intake to between 75 and 125 milligrams per day -- the recommended daily intake recommended by the Linus Pauling Institute at Oregon State University 13.
- One vitamin that can upset your stomach when taken in large doses is vitamin C, also called ascorbic acid.
Can I Overdose on Folic Acid?
Magnesium, an essential mineral, also may cause digestive upset following overconsumption. Magnesium plays a role in several processes within the body, with adequate magnesium thought to relieve the symptoms of premenstrual syndrome, irregular heart rhythms, diabetes and high blood pressure, according to the University of Maryland Medical Center 2. However, large doses of magnesium can prove harmful, leading to nausea and vomiting or even more severe symptoms such as low blood pressure, decreased heart rate or even death in some cases. Avoiding consuming large doses of magnesium through dietary supplements, and consult with a physician before taking magnesium supplements, to help avoid an upset stomach and other symptoms of magnesium overdose.
- Magnesium, an essential mineral, also may cause digestive upset following overconsumption.
- Magnesium plays a role in several processes within the body, with adequate magnesium thought to relieve the symptoms of premenstrual syndrome, irregular heart rhythms, diabetes and high blood pressure, according to the University of Maryland Medical Center 2.
Another mineral that may cause stomach or digestive upset is iron. This essential mineral plays a central role in the oxygenation of your cells and tissues. Iron makes up a portion of hemoglobin, a protein found on red blood cells. Hemoglobin binds oxygen from the air you inhale anf then carries that oxygen in your bloodstream, releasing it into your tissues. While deficiencies in iron can lead to health problems, including anemia, overdosing on iron can have negative side effects. The Linus Pauling Institute explains that iron overdose can cause nausea and vomiting and may even lead to kidney, liver and nervous system 13. Always consult with a physician before taking dietary supplements, including iron, to avoid negative side effects such as an upset stomach.
- Another mineral that may cause stomach or digestive upset is iron.
- The Linus Pauling Institute explains that iron overdose can cause nausea and vomiting and may even lead to kidney, liver and nervous system 1.
Can I Overdose on Folic Acid?
Can Magnesium Interact With Atenolol?
Is My Supplement with Calcium, Magnesium & Zinc Causing My Stinky Gas?
Does Iron Deficiency Cause Headaches?
Peanut Butter & Magnesium
Can You Get Dizzy After Taking Zinc?
Calcium Ascorbate Side Effects
Side Effects of Livaplex
Side Effects of Milk of Magnesia
Can Magnesium Supplements Interfere With Proper Blood Sugar Levels?
- Linus Pauling Institute: Vitamin C
- University of Maryland Medical Center: Magnesium
- Linus Pauling Institute: Iron
- Albahrani AA, Greaves RF. Fat-Soluble Vitamins: Clinical Indications and Current Challenges for Chromatographic Measurement. Clin Biochem Rev. 2016;37(1):27–47.
- Selhub J, Paul L. Folic acid fortification: why not vitamin B12 also? Biofactors. 2011;37(4):269-71. doi:10.1002/biof.173
- Ebben M, Lequerica A, Spielman A. Effects of pyridoxine on dreaming: a preliminary study. Percept Mot Skills. 2002;94(1):135-40. doi:10.2466/pms.2002.94.1.135
- U.S. National Library of Medicine. ToxNet: Nicotinic acid. Updated November 28, 2018.
- Chambial S, Dwivedi S, Shukla KK, John PJ, Sharma P. Vitamin C in disease prevention and cure: an overview. Indian J Clin Biochem. 2013;28(4):314–328. doi:10.1007/s12291-013-0375-3
- Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington (DC): National Academies Press; 2000.
- Golan D, Staun-ram E, Glass-marmor L, et al. The influence of vitamin D supplementation on melatonin status in patients with multiple sclerosis. Brain Behav Immun. 2013;32:180-5. doi:10.1016/j.bbi.2013.04.010
- Mason C, de Dieu Tapsoba J, Duggan C, Wang CY, Korde L, McTiernan A. Repletion of vitamin D associated with deterioration of sleep quality among postmenopausal women. Prev Med. 2016;93:166–170. doi:10.1016/j.ypmed.2016.09.035
- Rizvi S, Raza ST, Ahmed F, Ahmad A, Abbas S, Mahdi F. The role of vitamin E in human health and some diseases. Sultan Qaboos Univ Med J. 2014;14(2):e157–e165.
- DiNicolantonio JJ, Bhutani J, O'Keefe JH. The health benefits of vitamin K. Open Heart. 2015;2(1):e000300. doi:10.1136/openhrt-2015-000300
- NIH Osteoporosis and Related Bone Diseases National Resource Center. Calcium and Vitamin D: Important at Every Age. Updated October 2018.
- Ross AC. Dietary Reference Intakes for Calcium and Vitamin D. Washington, DC: National Academies Press; 2011.
- Straub DA. Calcium supplementation in clinical practice: a review of forms, doses, and indications. Nutr Clin Pract. 2007;22(3):286-96. doi:10.1177/0115426507022003286
- U.S. National Library of Medicine. ToxNet: Calcium Compounds. Updated January 29, 2000.
- Gröber U, Schmidt J, Kisters K. Magnesium in Prevention and Therapy. Nutrients. 2015;7(9):8199–8226. doi:10.3390/nu7095388
- U.S. National Library of Medicine. DailyMed: Milk of Magnesia. Updated October 19, 2018.
- Kantor ED, Rehm CD, Du M, White E, Giovannucci EL. Trends in Dietary Supplement Use Among US Adults From 1999-2012. JAMA. 2016;316(14):1464–1474. doi:10.1001/jama.2016.14403
Sylvie Tremblay holds a Master of Science in molecular and cellular biology and has years of experience as a cancer researcher and neuroscientist.