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Adverse Reactions to Vitamin D3

By Diane Marks

Vitamin D3 is primarily used to help the body absorb calcium. MedlinePlus states that vitamin D3 is most likely safe for most people, when taken as directed. As with any drug or supplement, you may experience minor to severe adverse reactions while taking the supplement. If you experience unwanted side effects after taking D3, discontinue use and call your doctor. In rare cases, a vitamin D3 reaction may cause a severe allergic reaction that could lead to death.

Common Reactions

Common adverse reactions to taking any vitamin are nausea, diarrhea, abdominal cramping and other digestive issues. If taking vitamin D3 causes unwanted digestive complications, try taking the supplement with meals or freezing the supplement before use. This can help reduce the common adverse reactions with vitamin D3.

Other Conditions

If you have been diagnosed with any other medical condition, you need to talk with your doctor before use. People with kidney disease, high levels of calcium in the blood, sarcoidosis, atherosclerosis, histoplasmosis or lymphoma should not use vitamin D3 supplements as it may cause complications and produce adverse reactions. Pregnant and breast-feeding women should not experience adverse reaction while taking vitamin D3 when using below 50 mcg daily. High doses can cause serious harm to the unborn baby, according to MedlinePlus.

Allergic Reactions

An allergic reaction may occur when taking vitamin D3, according to If you have an allergic reaction to vitamin D3, you will develop symptoms, such as nasal congestion, difficulty breathing, wheezing, coughing, diarrhea, stomach pain, vomiting, nausea or skin rashes, according to Health Tree. A severe allergic reaction can occur. Symptoms of a severe allergic reaction include dizziness, lightheadedness, hives, shortness of breath, a drop in blood pressure and an increased heart rate.

Too Much Vitamin D3

Taking too much D3 can led to adverse reactions, such as fatigue, sleepiness, weakness, loss of appetite, dry mouth, nausea, vomiting and a metallic taste in the mouth, according to MedlinePlus. The recommended dose of vitamin D3 daily is below 50 mcg. Taking too much can cause high levels of calcium in the blood which can lead to further complications.


If you experience adverse reactions after taking a vitamin D3 supplement, your doctor may ask you to participate in allergy testing. Allergy tests use a minor amount of the vitamin and place it under your skin to see if the skin develops inflammation. Your blood may be drawn to observe how it reacts when vitamin D3 is injected, according to Health Tree.

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