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At Healthfully, we strive to deliver objective content that is accurate and up-to-date. Our team periodically reviews articles in order to ensure content quality. The sources cited below consist of evidence from peer-reviewed journals, prominent medical organizations, academic associations, and government data.
- "International Journal of Obesity and Related Metabolic Disorders"; Ephedrine, Caffeine and Aspirin: Safety and Efficacy for Treatment of Human Obesity; P.A. Daly, et al.; February 1993
- "International Journal of Obesity and Related Metabolic Disorders"; Ephedrine, Caffeine and Aspirin: Safety and Efficacy for Treatment of Human Obesity; P.A. Daly, et al.; February 1993
- MayoClinic.com: Caffeine: Can It Help Me Lose Weight?
The information contained on this site is for informational purposes only, and should not be used as a substitute for the advice of a professional health care provider. Please check with the appropriate physician regarding health questions and concerns. Although we strive to deliver accurate and up-to-date information, no guarantee to that effect is made.
Weight Loss With Caffeine & Aspirin
Caffeine and aspirin were once used in combination with ephedrine in dietary supplements for weight loss. They're also found together in pain relievers, often with acetaminophen or butalbital. Caffeine should be used in moderation, and you should use aspirin only to treat mild to moderate pain or reduce fever or inflammation. A doctor may advise you to use it for other reasons, such as heart attacks, strokes and angina prevention.
Supplements
In a 2003 study in the "International Journal of Obesity and Related Metabolic Disorders," P.A 1. Daly and colleagues found that a combination of ephedrine, caffeine and aspirin could lead to modest, sustained weight loss. However, the Food and Drug Administration, or FDA, banned dietary supplements containing ephedrine in 2004 because of "unreasonable risk of illness or injury."
Ephedrine
Ephedrine Vs. Caffeine
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According to Drugs.com, common side effects of ephedrine are anxiety; confusion; difficulty sleeping; dizziness; headache; nausea; nervousness; pale skin; restlessness; sweating; tension; tremors; and weakness 2. Less common, severe side effects include:
- severe allergic reactions
- characterized by rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth
- face
- lips
- or tongue; chest pain; difficulty urinating; eye pain; hallucinations; increased irregular heartbeat; nausea; pounding in the chest;
- vomiting
Effects
Caffeine may cause slight weight loss or help you maintain your weight, according to MayoClinic.com 3. Caffeine may lead to temporary appetite suppression or increase the amount of calories that your body burns. It may also cause water loss, causing short-term weight reduction. Aspirin on its own does not appear to spur weight loss, but may increase the effects of ephedrine, according to a 1987 study by A.G. Dulloo and D.S 2. Miller published in the "American Journal of Clinical Nutrition."
Considerations
Congestive Heart Failure & Caffeine
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Studies do not show that weight loss from caffeine is permanent, and many studies were poor quality or only looked at caffeine's effect on animals, according to MayoClinic.com 3. Caffeine can be habit forming. Some people are more sensitive to its effects than others. Keep intake moderate. According to the McKinley Health Center of the University of Illinois at Urbana-Champaign, 300 mg of caffeine, or about the amount contained in 3 cups of coffee, is moderate intake.
- Studies do not show that weight loss from caffeine is permanent, and many studies were poor quality or only looked at caffeine's effect on animals, according to MayoClinic.com 3.
Warning
Caffeine can make you restless, anxious and irritable. It can also cause dizziness. Contact your health care provider if you experience diarrhea, shakiness, trouble sleeping or vomiting. Prolonged use of aspirin is not recommended unless a doctor advises you to use it for prevention of heart attack and stroke.
- Caffeine can make you restless, anxious and irritable.
- Contact your health care provider if you experience diarrhea, shakiness, trouble sleeping or vomiting.
Related Articles
References
- "International Journal of Obesity and Related Metabolic Disorders"; Ephedrine, Caffeine and Aspirin: Safety and Efficacy for Treatment of Human Obesity; P.A. Daly, et al.; February 1993
- Drugs.com: Ephedrine Side Effects
- MayoClinic.com: Caffeine: Can It Help Me Lose Weight?
- Meredith SE, Juliano LM, Hughes JR, Griffiths RR. Caffeine Use Disorder: A Comprehensive Review and Research Agenda. J Caffeine Res. 2013;3(3):114-130. doi:10.1089/jcr.2013.0016
- Richards G, Smith AP. A Review of Energy Drinks and Mental Health, with a Focus on Stress, Anxiety, and Depression. J Caffeine Res. 2016;6(2):49-63. doi:10.1089/jcr.2015.0033
- Brunyé TT, Mahoney CR, Rapp DN, Ditman T, Taylor HA. Caffeine enhances real-world language processing: evidence from a proofreading task. J Exp Psychol Appl. 2012;18(1):95-108. doi:10.1037/a0025851
- Koppelstaetter F, Poeppel TD, Siedentopf CM, et al. Caffeine and cognition in functional magnetic resonance imaging. J Alzheimers Dis. 2010;20 Suppl 1:S71-84. doi:10.3233/JAD-2010-1417
- Harrell PT, Juliano LM. Caffeine expectancies influence the subjective and behavioral effects of caffeine. Psychopharmacology (Berl). 2009;207(2):335-42. doi:10.1007/s00213-009-1658-5
- Lucas M, O'reilly EJ, Pan A, et al. Coffee, caffeine, and risk of completed suicide: results from three prospective cohorts of American adults. World J Biol Psychiatry. 2014;15(5):377-86. doi:10.3109/15622975.2013.795243
- Abdel-Hady H, Nasef N, Shabaan AE, Nour I. Caffeine therapy in preterm infants. World J Clin Pediatr. 2015;4(4):81-93. doi:10.5409/wjcp.v4.i4.81
- American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 5th edition. Washington DC; 2013.
- Turnbull D, Rodricks JV, Mariano GF, Chowdhury F. Caffeine and cardiovascular health. Regul Toxicol Pharmacol. 2017;89:165-185. doi:10.1016/j.yrtph.2017.07.025
- Centers for Disease Control and Prevention. Alcohol and Caffeine. Updated October 23, 2018.
- Alsunni AA. Energy Drink Consumption: Beneficial and Adverse Health Effects. Int J Health Sci (Qassim). 2015;9(4):468-474.
- Lyngsø J, Ramlau-Hansen CH, Bay B, Ingerslev HJ, Hulman A, Kesmodel US. Association between coffee or caffeine consumption and fecundity and fertility: a systematic review and dose-response meta-analysis. Clin Epidemiol. 2017;9:699-719. doi:10.2147/CLEP.S146496
- U.S. Food and Drug Administration. Pure and Highly Concentrated Caffeine. Updated September 21, 2018.
- National Institute on Drug Abuse. Drugs, Brains, and Behavior: The Science of Addiction. Updated July 2018.
Writer Bio
Erin Beck began writing professionally in 2008 as an opinion columnist for the West Virginia University student newspaper, "The Daily Athenaeum." She has worked in health promotion at the university and as a communications intern at the National Alliance on Mental Illness. She has a Bachelor of Science in journalism and a Master of Public Health, both from West Virginia University.