Citricidal Side Effects
Citricidal is a brand-name supplement, based on a component found in grapefruit pulp and seeds. Known as an antimicrobial compound, the seeds and pulp of grapefruit have a variety of properties, including use as a fungicide, antiviral and broad-spectrum, bacteria-fighting capabilities. Generally known for its low toxicity levels and safety, grapefruit seed extract is commonly purchased from drug stores and health food stores for its therapeutic antioxidant effects, to preserve cosmetics and foods, and in animal feed to help prevent parasites and mold, as well as a disinfectant for fish and poultry. However, as with anything, too much of a good thing can be bad for you. Some drug interactions are cautioned.
If you are experiencing serious medical symptoms, seek emergency treatment immediately.
Drug Interactions
Beware of potential drug interactions of prescribed medications and grapefruit seed extract 1. For example, some patients undergoing treatment for blood clotting issues who have been prescribed blood thinners such as warfarin may experience an increase in international normalized ratio blood test (INR), which defines the effectiveness of such medications to prevent blood clots while at the same time reducing the risk of uncontrolled bleeds in patients.
If you're taking immunosupressants, antihistamines or drugs or medications that lower cholesterol, avoid taking grapefruit seed extract or Citricidal as it may interfere with the function of the medication.
Digestive Health
How to Discontinue Plavix Before Surgery
Learn More
Take grapefruit seed extract as directed on bottle, as taking too much may kill the good bacteria in your digestive tract responsible for breaking down and digesting the contents of your stomach and intestines. Too much Citricidal or grapefruit seed extract in the system can destroy this bacteria, leading to inability of the digestive tract to function properly absorb nutrients, and may even lead to irritable bowel conditions that cause nausea and diarrhea.
Other Warnings
Pregnant women or those breastfeeding should not take Citricidal without first discussing its use with their doctor or pediatrician. In addition, people with bleeding disorders or conditions that require the use of blood thinners should not use Citricidal before any type of dental work or surgery, as it may prevent blood from clotting properly. You should stop using Citridical for at least two weeks before any such situations and to discuss potential or harmful side effects with your physician or health care provider.
Related Articles
References
- American Academy of Anti-Aging Medicine: Grapefruit Seed Extract
- Kang ST, Son HK, Lee HJ, Choi JS, Choi YI, Lee JJ. Effects of Grapefruit Seed Extract on Oxidative Stability and Quality Properties of Cured Chicken Breast. Korean J Food Sci Anim Resour. 2017;37(3):429–439. doi:10.5851/kosfa.2017.37.3.429
- Salehi B, Fokou PVT, Sharifi-Rad M, et al. The Therapeutic Potential of Naringenin: A Review of Clinical Trials. Pharmaceuticals (Basel). 2019;12(1):11. Published 2019 Jan 10. doi:10.3390/ph12010011
- Blumenthal, M. Adulteration of “Grapefruit Seed Extract,” etc.. HerbalGram (American Botanical Council) 2012; 94:6. HerbalGram.org
- Heggers JP, Cottingham J, Gusman J, et al. The effectiveness of processed grapefruit-seed extract as an antibacterial agent: II. Mechanism of action and in vitro toxicity. J Altern Complement Med. 2002;8(3):333-40.
- Dembinski A, Warzecha Z, Konturek SJ, et al. Extract of grapefruit-seed reduces acute pancreatitis induced by ischemia/reperfusion in rats: possible implication of tissue antioxidants. J Physiol Pharmacol. 2004;55(4):811–821.
- Cardellina, J.H. The Adulteration of Commercial “Grapefruit Seed Extract” with Synthetic, Antimicrobial and Disinfectant Compounds. HerbalGram (American Botanical Council) 2012; 94:62-66. HerbalGram.org
- Dwyer JT, Coates PM, Smith MJ. Dietary Supplements: Regulatory Challenges and Research Resources. Nutrients. 2018;10(1):41. Published 2018 Jan 4. doi:10.3390/nu10010041
- de Boer A, Bast A, Godschalk R. Dietary supplement intake during pregnancy; better safe than sorry?. Regul Toxicol Pharmacol. 2018;95:442–447. doi:10.1016/j.yrtph.2018.03.014
- Taghizadeh M, Malekian E, Memarzadeh MR, Mohammadi AA, Asemi Z. Grape Seed Extract Supplementation and the Effects on the Biomarkers of Oxidative Stress and Metabolic Profiles in Female Volleyball Players: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Iran Red Crescent Med J. 2016;18(9):e31314. Published 2016 Jul 17. doi:10.5812/ircmj.31314
- Den Hartogh DJ, Tsiani E. Antidiabetic Properties of Naringenin: A Citrus Fruit Polyphenol. Biomolecules. 2019;9(3):99. Published 2019 Mar 12. doi:10.3390/biom9030099
- Grapefruit Seed Extract. The Natural Medicines Database. Therapeutic Research Center. 2019
- Blumenthal, Mark. Adulteration of Grapefruit Seed Extract. American Botanical Council. 2012
- Dembinski A, Warzecha Z, Konturek SJ, Ceranowicz P, Dembinski M, Pawlik WW, Kusnierz-Cabala B, Naskalski JW. "Extract of grapefruit-seed reduces acute pancreatitis induced by ischemia/reperfusion in rats: possible implication of tissue antioxidants." J Physiol Pharmacol. 2004 Dec;55(4):811-21.
- Heggers JP, Cottingham J, Gusman J, Reagor L, McCoy L, Carino E, Cox R, Zhao JG. "The effectiveness of processed grapefruit-seed extract as an antibacterial agent: II. Mechanism of action and in vitro toxicity." J Altern Complement Med. 2002 Jun;8(3):333-40.
- Kang ST, Son HK, Lee HJ, Choi JS, Choi YI, Lee JJ. Effects of Grapefruit Seed Extract on Oxidative Stability and Quality Properties of Cured Chicken Breast. Korean J Food Sci Anim Resour. 2017;37(3):429–439. doi:10.5851/kosfa.2017.37.3.429
- Landberg R, Sun Q, Rimm EB, Cassidy A, Scalbert A, Mantzoros CS, Hu FB, van Dam RM. "Selected dietary flavonoids are associated with markers of inflammation and endothelial dysfunction in U.S. women." J Nutr. 2011 Apr 1;141(4):618-25.
Writer Bio
Denise Stern is an experienced freelance writer and editor. She has written professionally for more than seven years. Stern regularly provides content for health-related and elder-care websites and has an associate and specialized business degree in health information management and technology.