Fluoride is derived from fluorine, an element with unique properties that are ideal for synthesizing drugs 3. Fluorine is the most electronegative element and can substitute for hydrogen in medicinal compounds, making the compound stronger and more stable, acidic and lipophilic. These qualities increase the bioavailability of the drug and its ability to attach to binding sites on cellular receptors and enzymes. Fluorine-containing drugs are used to treat dental disease, neuropsychiatric disorders, cancer, infections and heart disease.

Fluoride for Teeth

Fluoride is used as a prescription drug to prevent tooth decay, strengthen teeth, resist acid and block cavity-forming bacteria, according to MedlinePlus 23. It is prescribed for adults and children who do not have access to fluoridated water. Fluoride should not be taken if the level in drinking water exceeds 0.7 parts per million, according to Drugs.com 35. Side effects from overdose of fluoride include:

• increase in saliva
  
• stomach pain
  
• vomiting
  
• diarrhea
  
• muscle stiffness
  
• skin rash
  
• tremors
  
• seizures 3

Some people may develop discolored teeth and weakened tooth enamel.

Fluoxetine

The active pharmaceutical ingredient in Prozac is fluoxetine hydrochloride, a chemical compound containing fluoride 3. Prozac is a prescription drug indicated for the treatment of depression, obsessive-compulsive disorder, bulimia nervosa and panic disorder, according to its product label.

Fluphenazine

Fluphenazine hydrochloride is the active ingredient in Prolixin, an antipsychotic prescription drug used to treat schizophrenia, according to Drugs.com 35. The actual chemical compound of the drug is a trifluoromethyl phenothiazine derivative that contains fluoride 3. The product label warns users that the drug can cause tardive dyskinesia, an involuntary movement disorder; neuroleptic malignant syndrome; and potential birth defects. Abrupt cessation of the drug may cause nausea, vomiting, dizziness and trembling.

5-Fluorouracil

A compound containing fluoride that is used to treat various types of cancer, according to the Cleveland Clinic and Drugs.com, is 5-fluorouracil 35. The chemotherapy drug is highly toxic, with a narrow margin for safety. There is a risk of blood toxicity, gastrointestinal bleeding and even death. The drug may also cause birth defects, so it should not be taken by pregnant women.

Tipranavir

Tipranavir is a fluoride-containing prescription drug that is known by the brand name Aptivus 3. Aptivus is indicated for treatment of HIV-1 infected patients. According to the product label, this medicine may cause liver toxicity and impairment, including inflammation, decomposition and bleeding in the brain. Fatalities have been reported from use of the drug.