What Are the Causes of Low White Blood Count & Fever?
The body produces two main categories of white blood cells, granulocytes, cells containing granules suspended within their plasma and agranulocytes which have no granules. Neutrophils, eosinophils and basophils are types of granulocytes. Lymphocytes and monocytes are agranulocytes. Each white blood cell type supports the immune system by performing specific functions in response to pathogens such as bacteria, viruses, allergens or parasites. When white blood count declines, immunity is compromised. Fever can ensue from a number of white blood cell related disorders.
AIDS
Acquired immunodeficiency syndrome can severely deplete white blood cell counts. This disease attacks the immune system and destroys its ability to fight off illnesses. KidsHealth explains that the AIDS virus specifically attacks lymphocyte cells called T-cells, taking control of them and causing them to multiply. This process causes damage to other T-cells, destroying them and lowering the white blood cell count. MedlinePlus notes that fever is a symptom of AIDS that may not manifest for years after the initial infection by the virus.
- Acquired immunodeficiency syndrome can severely deplete white blood cell counts.
- This disease attacks the immune system and destroys its ability to fight off illnesses.
Bone Marrow Disorders
What Are the Causes of Low Platelets & Low White Blood Cells?
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MayoClinic.com notes that numerous diseases that affect the bone marrow can lower the level of white blood cells and cause fever. This occurs because most white blood cells are formed in the bone marrow, though some are formed within the lymphatic glands as well. Myelodysplastic syndromes are bone marrow disorders that occur when the marrow produces immature and defective blood cells with an abnormally short life span. While myelokathexis is a congenital bone marrow disorder wherein the granulocytes contain genetic codes that predispose them to apoptosis, or cellular suicide. These cells die younger, causing lowered white blood cell counts.
- MayoClinic.com notes that numerous diseases that affect the bone marrow can lower the level of white blood cells and cause fever.
- While myelokathexis is a congenital bone marrow disorder wherein the granulocytes contain genetic codes that predispose them to apoptosis, or cellular suicide.
Medical Treatments
A person undergoing some medical treatments may find themselves with lower than normal white blood cell counts due to the effects of chemotherapy drugs or bone marrow transplants, according to MayoClinic.com, and with fever due to the effects of the underlying condition.
Radiation therapy can also destroy marrow tissue and lower white blood cell counts. Antibiotic drugs and diuretics have been implicated in lowering white blood cells levels as well.
Infection
Blood Cell Count & Infections
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When an infection is severe enough to overwhelm the immune system, a depletion of white blood cells may result. MayoClinic.com notes that some infections consume neutrophils at rates that are faster than the body can produce them, resulting in a white blood cell deficiency.
Related Articles
References
- MayoClinic.com: Myelodysplastic Syndromes
- Blood; Myelokathexis, a Congenital Disorder of Severe Neutropenia; AA Aprikyan, et al; January 2000
- KidsHealth: HIV and AIDS
- MedlinePlus: AIDS
- MayoClinic.com: Neutropenia
- U.S. Library of Medicine. MedlinePlus. White Blood Cell Count. https://medlineplus.gov/ency/article/003643.htm
- Mayadas TN, Cullere X, Lowell CA. The multifaceted functions of neutrophils. Annu Rev Pathol. 2014;9:181-218. doi:10.1146/annurev-pathol-020712-164023
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- Hoffman W, Lakkis FG, Chalasani G. B Cells, Antibodies, and More. Clin J Am Soc Nephrol. 2016;11(1):137-54. doi:10.2215/CJN.09430915
- Karlmark KR, Tacke F, Dunay IR. Monocytes in health and disease - Minireview. Eur J Microbiol Immunol (Bp). 2012;2(2):97-102. doi:10.1556/EuJMI.2.2012.2.1
- Görgens A, Radtke S, Horn PA, Giebel B. New relationships of human hematopoietic lineages facilitate detection of multipotent hematopoietic stem and progenitor cells. Cell Cycle. 2013;12(22):3478-82. doi:10.4161/cc.26900
- Hong JW, Noh JH, Kim DJ. Association between White Blood Cell Counts within Normal Range and Hemoglobin A1c in a Korean Population. Endocrinol Metab (Seoul). 2018;33(1):79-87. doi:10.3803/EnM.2018.33.1.79
- Riley LK, Rupert J. Evaluation of Patients with Leukocytosis. Am Fam Physician. 2015;92(11):1004-11.
- Flores-mireles AL, Walker JN, Caparon M, Hultgren SJ. Urinary tract infections: epidemiology, mechanisms of infection and treatment options. Nat Rev Microbiol. 2015;13(5):269-84. doi:10.1038/nrmicro3432
- Kasi PM, Grothey A. Chemotherapy-Induced Neutropenia as a Prognostic and Predictive Marker of Outcomes in Solid-Tumor Patients. Drugs. 2018;78(7):737-745. doi:10.1007/s40265-018-0909-3
- U.S. Library of Medicine. MedlinePlus. White Blood Cell Count.
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For 15 years, Charis Grey's award-winning work has appeared in film, television, newspapers, magazines and on the Internet. She has worked as a story editor on the CBS drama "Flashpoint" and her work appears bimonthly in "The Driver Magazine." She has a Bachelor of Science in biology and a doctorate in chiropractic medicine from Palmer College.