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- Mayo Clinic: Leuprolide (Intramuscular Route, Subcutaneous Route, Intradermal Route, Injection Route)
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Lupron is the brand name for the drug leuprolide. Leuprolide is used in children with early puberty to delay the onset of puberty. It is used in women to treat endometriosis and fibrroids; both are problems with the tissues of the uterus. In men, the drug is used to treat prostate cancer. It acts on the brain to stop the gonads from producing sex hormones. In affect, the drug is a form of medical castration. Therefore, the main side effects occur from deprivation of androgens such as testosterone, the male sex hormones.
If you are experiencing serious medical symptoms, seek emergency treatment immediately.
Allergic reactions to leupride are rare. They range in scope from mild reactions such as reddening itching or and hives at the site of injection to whole body skin involvement to anaphalyctic shock. Anaphylactic shock occurs when the allergen causes white blood cells of the body's immune system to release large amounts of histamine, dropping the blood pressure dangerously low. (See Reference 1)
Endocrine and Sexual Side Effects
Leuprolide primary effect is to change levels of hormones in the body to starve prostate cancer of growth factors. The absence of sex hormones also cause other unwanted side effects. (See Reference 1 and 2)
Whole-Body Side Effects
According to prescribing information published by the pharmaceutical company Abbot, side effects in the body as a whole included a general loss of strength in 12 percent of patients. Twelve percent of patients also experienced a flu-like syndrome. Thirty-three percent of patients felt general pain in the body, and 10 percent experienced headaches. (See Reference 3)
(See Reference 1)
Gastrointestinal Side Effects
Gastrointestinal side effects include anorexia, weight loss and weight gain, flatulence constipation, nausea and vomiting. According to the prescribing information from Abbot, about 10 percent of patients experience GI problems. (See Reference 1 and 3)
Nervous and Psychiatric System
Psychiatric side effects encompass insomnia, short-term memory loss, depression, anxiety and emotional mood swings and decreased libido. (See Reference 1)
Skin and Musculoskeletal System
Side effects in the skin have included rash, dry skin, itching, bruising, sensitivity to the sun, sweating, night sweats and changes in pigmentations.include:
- Side effects in the skin have included rash
- dry skin
- sensitivity to the sun
- night sweats
- changes in pigmentations
(See Reference 1)
(See Reference 1 and 2) According to prescribing information published by the pharmaceutical company Abbot, side effects in the body as a whole included a general loss of strength in 12 percent of patients. (See Reference 1) Leuprolide primary effect is to change levels of hormones in the body to starve prostate cancer of growth factors. (See Reference 1) During the initial stages, or about first two weeks of therapy, bone pain may increase.
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