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- "Chemotherapy" journal; "Relation of Arginine-lysine Antagonism to Herpes simplex Growth in Tissue Culture"; R.S. Griffith et al; June 1981
- "Chemotherapy" journal; "Relation of Arginine-lysine Antagonism to Herpes simplex Growth in Tissue Culture"; R.S. Griffith et al; June 1981
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Almonds and Herpes
Almonds have a reputation as a great source of fiber, protein and healthy fat. However, almonds' low lysine-to-arginine amino acid ratio has caused many who suffer from the herpes simplex virus to shun them. Herpes simplex is a virus that causes sores or lesions on the mouth and genital areas. Now, preliminary evidence suggests that almond skin extract may be beneficial to those suffering from the incurable, recurring disease.
If you are experiencing serious medical symptoms, seek emergency treatment immediately.
Theories/Speculation
Dietary recommendations for herpes most often focus on the lysine:arginine ratio. Lysine and arginine are two of 10 essential amino acids required by the body to build proteins required for normal functioning. Arginine is found in large quantities in nuts, grains, legumes and beans. In vitro (test tube) studies demonstrated that arginine is a food required for the growth of the herpes simplex virus, while lysine blocks the action of arginine, thus reducing viral replication 2. As a result, some say including more lysine in the diet and less arginine, effectively increasing the lysine:arginine ratio, will reduce herpes outbreaks.
- Dietary recommendations for herpes most often focus on the lysine:arginine ratio.
- As a result, some say including more lysine in the diet and less arginine, effectively increasing the lysine:arginine ratio, will reduce herpes outbreaks.
Significance of Almonds
Lysine Herpes Diet
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Almonds have a low lysine:arginine ratio, causing some to recommend their restriction, along with other nuts. However, dietary studies have not shown any reduction in herpes symptoms related to eating more foods with lysine while reducing arginine intake. Several small double-blind trials demonstrated reduction in either frequency of herpes outbreaks or herpes symptoms. However, no large-scale randomized controlled trials to date have confirmed the findings of smaller studies. In general, avoiding one particular food rich in arginine, such as almonds, is not recommended, according to the American Social Health Association. Furthermore, a physician should always be consulted prior to taking any dietary supplements.
- Almonds have a low lysine:arginine ratio, causing some to recommend their restriction, along with other nuts.
- In general, avoiding one particular food rich in arginine, such as almonds, is not recommended, according to the American Social Health Association.
Potential
Recent research by Giuseppina Mandalari and colleagues at the Institute of Food Research in the United Kingdom suggests a role for almond skin in reducing herpes outbreaks. The in-vitro study demonstrated a reduction in viral replication when natural almond skins were added to cells infected with herpes simplex. The authors suggest that an almond skin extract preparation may be beneficial to those with herpes. However, best-herpes-treatments.com still recommends avoiding almonds during an outbreak until further research confirming this finding is completed.
- Recent research by Giuseppina Mandalari and colleagues at the Institute of Food Research in the United Kingdom suggests a role for almond skin in reducing herpes outbreaks.
Expert Insight
Herpes & Arginine
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Currently, evidence from research studies is not strong enough to recommend avoidance or supplementation of almonds for those with herpes, according to the American Social Health Association. Almonds can be part of a balanced diet. Additionally, those interested in supplementing their diets with L-lysine should discuss this alternative treatment with their physicians.
Warning
Dietary supplements are not meant to replace medicine or treatment for those with herpes. Alternative treatments should be discussed with a physician prior to their use.
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References
- Herpes-coldsores: Diet and Nutrition with Herpes
- "Chemotherapy" journal; "Relation of Arginine-lysine Antagonism to Herpes simplex Growth in Tissue Culture"; R.S. Griffith et al; June 1981
- McQuillan G, Kruszon-Moran D, Flagg EW, Paulose-Ram R. Prevalence of herpes simplex virus type 1 and type 2 in persons aged 14–49: United States, 2015–2016. NCHS Data Brief. 2018;304.
- Tronstein E. Genital Shedding of Herpes Simplex Virus Among Symptomatic and Asymptomatic Persons With HSV-2 Infection. JAMA. 2011;305(14):1441. doi:10.1001/jama.2011.420
- World Health Organization (WHO). Herpes simplex virus. Updated January 31, 2017.
- Centers for Disease Control and Prevention. Genital Herpes - CDC Fact Sheet (Detailed). Updated January 31, 2017
- Centers for Disease Control and Prevention. Genital Herpes - CDC Fact Sheet. Updated August 28, 2017.
- Chun H, Carpenter R, Macalino G, Crum-Cianflone NF. The role of sexually transmitted infections in HIV-1 progression: A comprehensive review of the literature. Journal of Sexually Transmitted Diseases. 2012;2013(176459):1-15. doi:10.1155/2013/176459
- Heslop R, Roberts H, Flower D, Jordan V. Interventions for men and women with their first episode of genital herpes. Cochrane Database Syst Rev. 2016 Aug 30;(8):CD010684. doi:10.1002/14651858.CD010684.pub2
- Jin F, Prestage GP, Mao L, Kippax SC, Pell CM, et al. Transmission of herpes simplex virus types 1 and 2 in a prospective cohort of HIV-negative gay men: the health in men study. J Infect Dis. 2006 Sep 1;194(5):561-70.
- Schulte JM, Bellamy AR, Hook EW 3rd, Bernstein DI, Levin MJ, et al. HSV-1 and HSV-2 seroprevalence in the united states among asymptomatic women unaware of any herpes simplex virus infection (Herpevac Trial for Women). South Med J. 2014 Feb;107(2):79-84. doi:10.1097/SMJ.0000000000000062
Writer Bio
Amy Braglia-Tarpey is a registered dietitian who has previously published articles in DaVita Inc.'s publications "Lifelines" and "KEYp Newsletter." She has a master's degree in nutritional science from California State University Long Beach. She has also earned Certified Nutrition Support Clinician and Certified Specialist in Renal Nutrition designations.