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Medicines That Cause Excessive Sweating

Many medicines cause excessive sweating, or hyperhidrosis, as a side effect. The International Hyperhidrosis Society lists approximately 400 medications that can cause sweating and points out that the list is not complete 1. Patients should discuss excessive sweating believed to be caused by a medication with the prescribing physician.

Is This an Emergency?

If you are experiencing serious medical symptoms, seek emergency treatment immediately.


Antidepressant medications commonly cause sweating, especially those that regulate the amount of the brain chemical serotonin. Selective serotonin reuptake inhibitors, or SSRIs, that cause:

  • sweating include paroxetine
  • or Paxil; fluoxetine
  • or Prozac;
  • citalopram
  • or Celexa

Serotonin norepinephrine reuptake inhibitors, or SNRIs, that are known to increase sweating include

  • venlafaxine
  • or Effexor;
  • duloxetine
  • or Cymbalta

It is not known why these antidepressants increase sweating, the International Hyperhydrosis Society notes 1.


Drugs That Would Cause Excessive Sweating

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Synthroid, known generically as levothyroxine, is a thyroid hormone replacement used when the thyroid gland does not produce enough of the hormone thyroxine 3. Thyroxine is necessary for the control of vital functions of metabolism, including body temperature regulation through shivering and sweating. A side effect of Synthroid is excessive sweating, according to Cerner Multum, a healthcare information provider 3. Hot flashes and fever, other side effects of Synthroid, may occur along with increased sweating 3. These side effects should be reported to a physician.


Evoxac, or cevimeline, is a cholinergic drug indicated for the treatment of Sjogren's syndrome, a chronic inflammatory disease that often occurs in people with autoimmune disorders such as rheumatoid arthritis and lupus 4. Sjogren's syndrome causes the mucous membranes to become very dry, and it affects the mouth and eyes in particular. Evoxac increases secretions such as saliva and tears to alleviate the dryness, but it also increases sweating 4. Excessive sweating is a common side effect. Evoxac users must be careful to avoid dehydration due to increased sweating 4.

Zinc Supplements

Herbal Remedies for Hyperhidrosis

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Zinc supplements are used to treat a deficiency of zinc, a nutrient necessary for metabolism, wound healing, skin hydration and the senses of smell and taste. Zinc is also used in lozenge form in preparations such as Cold-Eeze, indicated to reduce the length and severity of cold symptoms. Profuse sweating is a common symptom of an overdose of zinc, and sufferers should seek medical attention.