St John's Wort & Food Interactions

St. John's Wort has been recommended for centuries as a treatment for a wide variety of illnesses 3. Otherwise known as Hypericum Perforatum L. or goat weed, extracts from the leaves and flowers of the plant today are often used by some people for mild to moderate depression and anxiety. While interactions with specific drugs have been well discussed and are common knowledge, there has also been some concern expressed about possible interactions with specific foods and St. John's Wort 3.

Is This an Emergency?

If you are experiencing serious medical symptoms, seek emergency treatment immediately.

St. John's Wort and Depression

Current research has shown that St. John's Wort has been effective in relieving symptoms of mild to moderate depression for short-term use 3. According to an article published in Psychosomatics, short-term use is defined to as one to three months. Long-term implications of the drug have not been assessed. This differs from recommendations by Dr. Andrew Weil, who suggests taking 300 mg twice three times daily and anticipating a two-month delay before the antidepressant activity is noticeable. St. John's Wort has not been proven effective for severe depression or cancer 3.


Experimentally, St John's Wort has functioned as a weak MAO inhibitor 23. MAO inhibitors are a strong class of medications used to treat depression. Generally, foods that are high in tyramine are avoided with MAO inhibitors. According to the review article in Psychosomatics, there have been reported incidents of MAO-type interactions in humans with St. John's Wort but the occurrences are rare 13.

That said, it would be wise to avoid large quantities of foods high in tyramine while taking St. John's Wort so that you do not risk the chance of a hypertensive crisis 3. Foods high in tyramine include aged meats and cheeses, red wine and overripe avocados. Please see the reference section for a full list of these foods. See your physician immediately if you feel flushed and have a crushing headache after eating these foods and taking St. John's Wort 3.


Many supplements contain properties that thin the blood. This is generally a good thing for people who are healthy and not taking additional blood-thinning medications such as Coumadin. These properties are also found in the food supply. Dark, leafy greens, asparagus, broccoli and sauerkraut are all high in Vitamin K. If you are taking St. John's Wort and are already being told to limit these foods, you may find the herb is making it difficult to set your medication properly 3. Please inform your physician.

Iron Absorption

St. John's Wort contains tannins that may theoretically have an impact on iron absorption 3. Tannins are compounds naturally found in teas and wine and have been known to inhibit the absorption of iron. Consider taking the herb separately from high-iron foods as a precaution.

Expert Insight

The biggest concerns with St. John's Wort are its interactions with specific medications 3. Like with all supplements, discuss both your intent to take the herb and your depressive symptoms with a medical professional and your pharmacist before starting a regimen. Depression can be a very serious medical condition and you should be assessed by a professional trained to manage your symptoms.