What does fact checked mean?
At Healthfully, we strive to deliver objective content that is accurate and up-to-date. Our team periodically reviews articles in order to ensure content quality. The sources cited below consist of evidence from peer-reviewed journals, prominent medical organizations, academic associations, and government data.
The information contained on this site is for informational purposes only, and should not be used as a substitute for the advice of a professional health care provider. Please check with the appropriate physician regarding health questions and concerns. Although we strive to deliver accurate and up-to-date information, no guarantee to that effect is made.
A majority of medications must pass through the liver to be broken down and distributed to the rest of the body. Liver injury due to medical complications can sometimes impede the proper metabolizing of drugs in the body. However, liver injury due to use of certain drugs may also cause damage. The Foundation for the National Institutes of Health notes that acute liver failure due to prescription and non-prescription medication is a growing problem in the United States.
If you are experiencing serious medical symptoms, seek emergency treatment immediately.
Acetaminophen is a commonly used medication that can relieve pain and reduce a fever. Although considered a safe medication when taken as directed, the American Association for the Study of Liver Diseases warns that accidental acetaminophen overdose is the most common cause of acute liver failure in the United States, with 500 deaths per year attributed to overdose of acetaminophen. This drug produces toxic byproducts that the liver breaks down and flushes out. However, in too large a dose or when mixed with other drugs, the process of detoxifying is compromised and leads to damage of the liver.
- Acetaminophen is a commonly used medication that can relieve pain and reduce a fever.
- However, in too large a dose or when mixed with other drugs, the process of detoxifying is compromised and leads to damage of the liver.
The Effect of Ibuprofen on the Liver
Valproic acid is a medication used for treating seizure disorders and symptoms of mania and depression in people with bipolar disorder 1. MedllinePlus warns that this medication may cause serious damage to the liver, especially to those taking more than one form of anti-convulsant medication. According to the Epilepsy Therapy Project, symptoms associated with possible liver damage from this medication include lethargy, facial swelling and yellowing of the skin, also known as jaundice. Liver damage from this drug is usually prominent within the first six months of beginning the medication.
- Valproic acid is a medication used for treating seizure disorders and symptoms of mania and depression in people with bipolar disorder 1.
- MedllinePlus warns that this medication may cause serious damage to the liver, especially to those taking more than one form of anti-convulsant medication.
Some antibiotics cause liver damage due to accumulation of waste instead of the proper breakdown of substances. When the drugs are not metabolized effectively, toxicity may occur, which changes the intended function of the medication. The Hepatitic C Resources and Support website notes that liver inflammation from antibiotics such as penicillin is possible, especially in people with already compromised liver functions.
The Effect of Ibuprofen on the Liver
Can Hydroxycut Interfere With Other Medications Like Amoxicillin?
Dangers of Tylenol PM
Medications That Cause Fatty Liver
Side Effects of Tandrilax
Dangers of Fluoride Prescription Drugs
Bad Breath and Lactose Intolerance
The Effects of Ibuprofen on the Liver & Kidneys
How Long Does Tylenol Stay in Your System?
Keflex and Sulfa Allergies
- MedlinePlus: Valproic Acid
- Cleveland Clinic. Cirrhosis of the Liver. Reviewed January 11, 2019.
- David S, Hamilton JP. Drug-induced Liver Injury. US Gastroenterol Hepatol Rev. 2010;6:73–80.
- American Liver Foundation. Medications.
- Cleveland Clinic Health Essentials. Is Acetaminophen Safe to Take When You're Drinking? Published December 19, 2017.
- University of Michigan, Michigan Medicine. Methyldopa. Revised September 17, 2018.
- Elsevier Science Direct. Hypervitaminosis A. Published 2015.
- National Center for Biotechnology Information, U.S. National Library of Medicine. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury: Vitamin A. Updated December 3, 2013.
- National Center for Biotechnology Information, U.S. National Library of Medicine. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury: Niacin. Updated February 2, 2014.
- Amathieu R, Levesque E, Merle JC, et al. Insuffisances hépatiques aiguës sévères d'origine toxique : prise en charge étiologique et symptomatique [Severe toxic acute liver failure: etiology and treatment]. Ann Fr Anesth Reanim. 2013;32(6):416–421. doi:10.1016/j.annfar.2013.03.004
- Devarbhavi H. An Update on Drug-induced Liver Injury. J Clin Exp Hepatol. 2012;2(3):247–259. doi:10.1016/j.jceh.2012.05.002
- Johns Hopkins Medicine. Drug-Induced Hepatitis.
Aubri John has been a contributing researcher and writer to online physical and mental health oriented journals since 2005. John publishes online health and fitness articles that coincide with her licensed clinical skills in addictions, psychology and medical care. She has a master's degree in clinical social work and a Ph.D. in health psychology.