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- National Institute of Neurological Disorders and Stroke: Huntington's Disease
- MayoClinic.com: Huntington's Disease - Symptoms
- Genetics Home Reference: What is Huntington Disease?
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Early Symptoms of Huntington's Disease
Huntington's disease is genetic disorder characterized by the progressive degradation of nerves within the brain 2. At least 15,000 people within the United States currently have Huntington's disease, according to the National Institute of Neurological Disorders and Stroke 12. Patients who develop any of the early symptoms of Huntington's disease should speak with a physician for further evaluation and care 2.
If you are experiencing serious medical symptoms, seek emergency treatment immediately.
Personality Changes
Patients with this condition can develop sudden or significant personality changes as an early symptom of Huntington's disease 2. Affected patients can become unusually irritable or depressed, or may experience severe mood swings. These early Huntington's disease symptoms can negatively affect a patient's social, work and familial relationships 2. Patients who experience sudden personality changes should seek additional care from a medical professional immediately.
Decreased Cognitive Abilities
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During the early stage of this disease, the nerves within the brain, called neurons, may begin to malfunction. As a result, patients with Huntington's disease can exhibit cognitive deficits as a symptom of this condition 2. Affected patients may have difficulty making decisions or performing newly learned tasks. Certain patients may appear forgetful or struggle to answer questions during normal conversations, warns MayoClinic.com. These early symptoms of Huntington's disease can be frustrating or overwhelming to both the patient and family or friends 2. Patients who experience sudden or unusual cognitive changes should speak with a medical professional for further care.
Balance Problems
Poor neuron function can affect a patient's ability to move about normally. As a result, patients with Huntington's disease can develop balance problems as an early symptom 2. Affected patients may appear unstable or require assistance while standing or walking.
Jerking or Twitching
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Patients with Huntington's disease can develop unusual, involuntary jerking or twitching of the body--a condition called chorea--as an early symptom, reports Genetics Home Reference, an informational website on genetic conditions that is supported by the National Institutes of Health 23. These uncontrolled movements can affect any region of the body, including the face, arms or legs. Patients who develop these early Huntington's disease symptoms should speak with a medical provider immediately 2.
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References
- National Institute of Neurological Disorders and Stroke: Huntington's Disease
- MayoClinic.com: Huntington's Disease - Symptoms
- Genetics Home Reference: What is Huntington Disease?
- University of California San Francisco Medical Center: Huntington's Disease
- Huntington’s Disease Society of America. (2019). Overview of Huntington’s Disease.
- Huntington’s Disease Society of America. (2019). Huntington's Disease Stages.
- Roos RA. Huntington's disease: a clinical review. Orphanet J Rare Dis. 2010 Dec 20;5:40. doi:10.1186/1750-1172-5-40.
- Genetics Home Reference. (2019). Huntington's Disease. Updated November 12, 2019.
- Genetic and Rare Diseases Information Center. Huntington disease.
- Frank S. Treatment of Huntington's Disease. Neurotherapeutics. 2014 Jan;11(1):153-60.
- Kocsis B. (June 2015). UC Davis Healthsystem: Challenging Behaviors in Huntington’s Disease: Strategies for Patients and Families.
- Coppen EM, Roos RA. Current Pharmacological Approaches to Reduce Chorea in Huntington's Disease. Drugs. 2017 Jan;77(1):29-46. doi:10.1007/s40265-016-0670-4.
- National Institute of Neurological Disorders and Stroke. National Institute of Health. NINDS Huntington's Disease Information Page.
- Roos RA. Huntington's disease: a clinical review. Orphanet J Rare Dis. 2010 Dec 20;5:40. doi:10.1186/1750-1172-5-40.
Writer Bio
Rae Uddin has worked as a freelance writer and editor since 2004. She specializes in scientific journalism and medical and technical writing. Her work has appeared in various online publications. Uddin earned her Master of Science in integrated biomedical sciences with an emphasis in molecular and cellular biochemistry from the University of Kentucky College of Medicine.