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At Healthfully, we strive to deliver objective content that is accurate and up-to-date. Our team periodically reviews articles in order to ensure content quality. The sources cited below consist of evidence from peer-reviewed journals, prominent medical organizations, academic associations, and government data.
- Journal of Alternative and Complementary Medicine: The Effectiveness of Processed Grapefruit-Seed Extract as an Antibacterial Agent: II. Mechanism of Action and In Vitro Toxicity
- Journal of Alternative and Complementary Medicine: The Effectiveness of Processed Grapefruit-Seed Extract as an Antibacterial Agent: II. Mechanism of Action and In Vitro Toxicity
The information contained on this site is for informational purposes only, and should not be used as a substitute for the advice of a professional health care provider. Please check with the appropriate physician regarding health questions and concerns. Although we strive to deliver accurate and up-to-date information, no guarantee to that effect is made.
Grapefruit Seed Extract for a Yeast Infection
Yeast infections are a common occurrence for women, with three out of four women experiencing one in their lifetime according to FamilyDoctor.org. Several methods, both prescription and nonprescription, are available to treat them. One natural treatment that is inexpensive and purported by natural health practitioners to be effective is the ingestion of grapeseed extract, or GSE. This supplement acts as a nature-based antibiotic and antifungal that kills off proliferating yeast.
Action
GSE comes from the rind and seeds of the grapefruit 4. According to DiagnoseMe.com, a website overseen by medical doctors, it is a broad-spectrum, natural antibiotic that can kill a wide variety of pathogens. Along with bacteria and protozoa, it kills the yeast in both vaginal and systemic yeast infections. It is considered generally safe for most people and can be used for long periods of time without upsetting the beneficial flora in the gut, unlike antibiotics.
Dr. Allan Sachs, a proponent of using GSE for candida, recommends that a cleansing diet that is low in sugar and starches be used in conjunction to remove the yeast.
- GSE comes from the rind and seeds of the grapefruit 4.
- Dr. Allan Sachs, a proponent of using GSE for candida, recommends that a cleansing diet that is low in sugar and starches be used in conjunction to remove the yeast.
Availability
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Grapefruit seed extract can be found in most health food stores, in either pill or liquid form 12. It is also found at most drug stores and on the Internet. Some GSE products contain additional compounds, such as preservatives and fillers. Check the label to see exactly what you are buying.
- Grapefruit seed extract can be found in most health food stores, in either pill or liquid form 1.
Dosage
In "Nature's Antiseptics: Tea Tree Oil and Grapefruit Seed Extract", author C. J. Puotinen recommends three or more capsules, or 10 to 20 drops of liquid extract, of GSE per day to fight a yeast infection 13. Dr. Sachs recommends using GSE as a douche -- 16 drops in 16 ounces of water, once a day for three days. You should discuss exact amounts of GSE for both oral and vaginal use with a doctor.
Studies
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A study from the University of Texas found that GSE has "antimicrobial properties," is safe, and affects bacteria within 15 minutes. Other studies have failed to prove the effectiveness of GSE against fungus.
Contraindications
Those with a citrus allergy should not take GSE. It should not be used with immunosuppressant or cholesterol lowering medications or taken with antihistamines.
Related Articles
References
- Diagnose Me: Grapefruit Seed Extract
- PositiveHealthOnline.com: Treating Candida with Grapefruit Seed Extract
- Nature's Antiseptics: Tea Tree Oil and Grapefruit Seed Extract; C. J. Puotinen
- Journal of Alternative and Complementary Medicine: The Effectiveness of Processed Grapefruit-Seed Extract as an Antibacterial Agent: II. Mechanism of Action and In Vitro Toxicity
- Natural Ingredient Resource Center: Grapefruit Seed Extract
- Kang ST, Son HK, Lee HJ, Choi JS, Choi YI, Lee JJ. Effects of Grapefruit Seed Extract on Oxidative Stability and Quality Properties of Cured Chicken Breast. Korean J Food Sci Anim Resour. 2017;37(3):429–439. doi:10.5851/kosfa.2017.37.3.429
- Salehi B, Fokou PVT, Sharifi-Rad M, et al. The Therapeutic Potential of Naringenin: A Review of Clinical Trials. Pharmaceuticals (Basel). 2019;12(1):11. Published 2019 Jan 10. doi:10.3390/ph12010011
- Blumenthal, M. Adulteration of “Grapefruit Seed Extract,” etc.. HerbalGram (American Botanical Council) 2012; 94:6. HerbalGram.org
- Heggers JP, Cottingham J, Gusman J, et al. The effectiveness of processed grapefruit-seed extract as an antibacterial agent: II. Mechanism of action and in vitro toxicity. J Altern Complement Med. 2002;8(3):333-40.
- Dembinski A, Warzecha Z, Konturek SJ, et al. Extract of grapefruit-seed reduces acute pancreatitis induced by ischemia/reperfusion in rats: possible implication of tissue antioxidants. J Physiol Pharmacol. 2004;55(4):811–821.
- Cardellina, J.H. The Adulteration of Commercial “Grapefruit Seed Extract” with Synthetic, Antimicrobial and Disinfectant Compounds. HerbalGram (American Botanical Council) 2012; 94:62-66. HerbalGram.org
- Dwyer JT, Coates PM, Smith MJ. Dietary Supplements: Regulatory Challenges and Research Resources. Nutrients. 2018;10(1):41. Published 2018 Jan 4. doi:10.3390/nu10010041
- de Boer A, Bast A, Godschalk R. Dietary supplement intake during pregnancy; better safe than sorry?. Regul Toxicol Pharmacol. 2018;95:442–447. doi:10.1016/j.yrtph.2018.03.014
- Taghizadeh M, Malekian E, Memarzadeh MR, Mohammadi AA, Asemi Z. Grape Seed Extract Supplementation and the Effects on the Biomarkers of Oxidative Stress and Metabolic Profiles in Female Volleyball Players: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Iran Red Crescent Med J. 2016;18(9):e31314. Published 2016 Jul 17. doi:10.5812/ircmj.31314
- Den Hartogh DJ, Tsiani E. Antidiabetic Properties of Naringenin: A Citrus Fruit Polyphenol. Biomolecules. 2019;9(3):99. Published 2019 Mar 12. doi:10.3390/biom9030099
- Grapefruit Seed Extract. The Natural Medicines Database. Therapeutic Research Center. 2019
- Blumenthal, Mark. Adulteration of Grapefruit Seed Extract. American Botanical Council. 2012
- Dembinski A, Warzecha Z, Konturek SJ, Ceranowicz P, Dembinski M, Pawlik WW, Kusnierz-Cabala B, Naskalski JW. "Extract of grapefruit-seed reduces acute pancreatitis induced by ischemia/reperfusion in rats: possible implication of tissue antioxidants." J Physiol Pharmacol. 2004 Dec;55(4):811-21.
- Heggers JP, Cottingham J, Gusman J, Reagor L, McCoy L, Carino E, Cox R, Zhao JG. "The effectiveness of processed grapefruit-seed extract as an antibacterial agent: II. Mechanism of action and in vitro toxicity." J Altern Complement Med. 2002 Jun;8(3):333-40.
- Kang ST, Son HK, Lee HJ, Choi JS, Choi YI, Lee JJ. Effects of Grapefruit Seed Extract on Oxidative Stability and Quality Properties of Cured Chicken Breast. Korean J Food Sci Anim Resour. 2017;37(3):429–439. doi:10.5851/kosfa.2017.37.3.429
- Landberg R, Sun Q, Rimm EB, Cassidy A, Scalbert A, Mantzoros CS, Hu FB, van Dam RM. "Selected dietary flavonoids are associated with markers of inflammation and endothelial dysfunction in U.S. women." J Nutr. 2011 Apr 1;141(4):618-25.
Writer Bio
Christine Garvin is a certified nutrition educator and holds a Master of Arts in holistic health education. She is co-editor of Brave New Traveler and founder/editor of Living Holistically... with a sense of humor. When she is not out traveling the world, she is busy writing, doing yoga and performing hip-hop and bhangra.