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How to Treat Acne With Aldactone

By Sandra Ketcham ; Updated July 18, 2017

Aldactone (spironolactone) is an aldosterone receptor antagonist medication that is sometimes used off-label in the treatment of hormonal acne in women. DERMAdoctor states that Aldactone mimics androgen hormones in the body, enabling it to bind to androgen receptors and reduce levels of natural androgen. According to the Acne Resource Center Online, androgen plays a significant role in oil production by the sebaceous glands, and reducing oil production helps improve or eliminate acne in some women.

  1. Visit your dermatologist for a complete exam and hormone testing. Not all cases of adult acne are related to excess androgen. According to Acne Resource Center Online, you are more likely to benefit from taking Aldactone if you also suffer from irregular periods, obesity, diabetes, infertility or other symptoms and conditions associated with a hormonal imbalance.

  2. Begin with a dose of 25 mg, once per day, unless your doctor instructs otherwise. The American Academy of Family Physicians states that doses of 100 to 200 mg daily may be necessary to treat hormonal acne in adult women. Your doctor will devise a plan to gradually increase your dose to this level.

  3. Take your medication in the morning, at the same time each day, and with a meal or a full glass of water. If you are to take Aldactone twice daily, split the doses evenly, with one dose in the morning and the second before bed.

  4. Continue taking Aldactone even if you do not notice improvement in your acne right away. It may take several weeks for the medication to become fully effective, according to

  5. Speak with your doctor if you have concerns about side effects caused by this medication. According to, normal side effects of Aldactone include mild nausea, headache, dizziness, stomach pain and increased gas. These side effects generally lessen within a few months of beginning treatment. Taking birth control pills in combination with Aldactone may reduce the severity of side effects. A study published in the November 2002 issue of Journal of Cutaneous Medicine and Surgery found that use of Aldactone in the treatment of acne was safe, and that side effects, while common, are rarely cause for discontinuation of therapy.

  6. Tell your doctor before taking Aldactone if you are already taking potassium supplements, amiloride, triamtereme, ACE inhibitors, non-steroidal anti-inflammatory medications, barbiturates, diuretics, narcotic pain relievers or oral steroids. The National Institutes of Health (NIH) states that these medications may interact with Aldactone. Also, tell your doctor if you have kidney or liver disease or if you are pregnant. Do not breastfeed while taking this medication.

  7. Avoid drinking alcohol while taking Aldactone to treat acne. Doing so can cause lightheadedness, dizziness, or fainting, according to the NIH.

  8. Reduce or eliminate potassium-rich foods, such as bananas, raisins, prunes, raisins and orange juice, from your diet. also recommends limiting your sodium intake, as sodium causes the body to retain water and may make Aldactone less effective.

  9. Store this medication in a tightly sealed container, out of the reach of children. Do not keep Aldactone in warm or moist locations, such as in your bathroom or near your kitchen sink.

  10. Keep all appointments with your doctor, and undergo frequent blood testing to make sure the medication is working and is not causing harmful effects. Your hormone levels need to be monitored so that your doctor can adjust your dose when necessary.

  11. Tip

    According to the American Academy of Dermatology, acne is very common in adult women, with more than half of women aged 20 to 29 years experiencing at least occasional breakouts. Aldactone is sometimes prescribed to treat acne associated with polycystic ovary syndrome, a condition that affects as many as 5 million American women, according to the U.S. Department of Health and Human Services.


    The National Institutes of Health warns that Aldactone has caused tumor formation in laboratory animals. Seek emergency medical attention for symptoms of overdose, such as confusion, skin rash, drowsiness, diarrhea, nausea or vomiting.

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