What Causes Hot Flashes Besides Menopause?
Hot Flash Basics
Hot flashes are one of the characteristic signs of menopause 1. The sudden wash of heat across your face and entire upper body, sweating, racing heart and nausea are just the beginning. Other symptoms include feeling weak, difficulty catching your breath and a sudden headache. While hot flashes are most frequently associated with menopause, "the change" isn't the only cause of hot flashes 1.
Hormones
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There may be many different causes of hot flashes, but hormones are always at the root of the problem 1. When estrogen reaches low levels, it affects the hypothalamus in the brain. The hypothalamus manages several body functions, including sleep, regulation of sex hormones and the temperature within your body. When hormone levels fluctuate, so does your body temperature--and hot flashes result 1.
Medications
Women taking the drug tamoxifen to treat breast cancer often experience hot flashes 13. The drug affects hormone levels, and hot flashes are a common side effect 1. Tamoxifen works against the effects of estrogen, which can fuel breast cancer. Women may experience hot flashes from tamoxifen while the body gets used to the drug 1. Some women suffer hot flashes after discontinuing medication use 1. While tamoxifen doesn't trigger menopause, its effect on estrogen is significant enough to trigger hot flashes 1.
Conditions
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Cancer seems to be related to hot flashes, due to its treatments 13. Menopause can happen for different reasons, which may all trigger hot flashes 1. Women with cancer may undergo menopause that has been induced by treatments. Chemotherapy and surgery to remove some reproductive organs can be behind hot flashes during cancer treatment 13.
Surgery
Surgery to remove reproductive organs--a hysterectomy--can induce menopause and all its symptoms. Surgically-induced menopause causes hot flashes because of the changes in estrogen levels when sex organs, including the ovaries, are removed 1.
The Bottom Line
Hormone levels, specifically the hormone estrogen, signal the brain to control the body's temperature. When estrogen is affected, for whatever reason, hot flashes can result 1. Menopause is most often the cause, whether it's your body's natural time or it's been induced by medications or surgery. Any condition, medication or surgery that stops estrogen production or interferes with its effects may result in hot flashes 1.
Related Articles
References
- Mayo Clinic -- Hot Flashes
- Breastcancer.org -- Hot Flashes
- National Cancer Institute -- Hot Flashes
- Fontein DB, Seynaeve C, Hadji P, et al. Specific adverse events predict survival benefit in patients treated with tamoxifen or aromatase inhibitors: an international tamoxifen exemestane adjuvant multinational trial analysis. J Clin Oncol. 2013;31(18):2257-64. doi:10.1200/JCO.2012.45.3068
- Majumder A, Singh M, Tyagi SC. Post-menopausal breast cancer: from estrogen to androgen receptor. Oncotarget. 2017;8(60):102739–102758. doi:10.18632/oncotarget.22156
- Fei C, DeRoo LA, Sandler DP, Weinberg CR. Menopausal symptoms and the risk of young-onset breast cancer. Eur J Cancer. 2013;49(4):798–804. doi:10.1016/j.ejca.2012.08.030
- American Cancer Society. Hormone Therapy for Breast Cancer. Updated September 18, 2019.
- Pan H, Gray R, Braybrooke, J, et al. 20-Year Risks of Breast-Cancer Recurrence after Stopping Endocrine Therapy at 5 Years. The New England Journal of Medicine. 2017;377:1836-1846. doi:10.1056/NEJMoa1701830
- Fontein DB, Houtsma D, Hille ET, et al. Relationship between specific adverse events and efficacy of exemestane therapy in early postmenopausal breast cancer patients. Ann Oncol. 2012;23(12):3091-7. doi:10.1093/annonc/mds204
- Fontein, D., Charehbili, A., Nortier, J. et al. Specific Adverse Events are Associated with Response to Exemastane Therapy in Postmenopausal Breast Cancer Patients: Results from the TEAMIA Study (BOOG2006-04). European Journal of Surgical Oncology. 2016 Dec 10.
- Huang, Y., Malone, K., Cushing-Haugen, K., Daling, J., and C. Li. Relationship Between Menopausal Symptoms and Risk of Postmenopausal Breast Cancer. Cancer Epidemiology Biomarkers and Prevention. 2011. 20(2):379-88.
- Breastcancer.org. Soy. Updated January 15, 2014.
- Kligman L, Younus J. Management of hot flashes in women with breast cancer. Curr Oncol. 2010;17(1):81–86. doi:10.3747/co.v17i1.473
- Leon-Ferre R, Novotny P, Faubion S, et al. Abstract GS6-02: A randomized, double-blind, placebo-controlled trial of oxybutynin (Oxy) for hot flashes (HF): ACCRU study SC-1603. General Session Abstracts. 2019. doi:10.1158/1538-7445.sabcs18-gs6-02.
- Nesaretnam K, Meganathan P, Veerasenan SD, Selvaduray KR. Tocotrienols and breast cancer: the evidence to date. Genes Nutr. 2012;7(1):3–9. doi:10.1007/s12263-011-0224-z
- American Cancer Society. Benefits of good nutrition during cancer treatment. Updated July 15, 2019.
- Pan H, Gray R, Braybrooke, J, et al. 20-Year Risks of Breast-Cancer Recurrence after Stopping Endocrine Therapy at 5 Years. The New England Journal of Medicine. 2017;377:1836-1846. doi:10.1056/NEJMoa1701830
Writer Bio
Diana Rodriguez is a Louisville, Kentucky-based full-time freelance writer who specializes in health and real-estate writing. Since 2008 her numerous articles have appeared on various news and health websites. She also specializes in custom Web content for a variety of businesses. She has degrees in journalism and French from Miami University of Ohio.